Report of the workflow results

Author

Ellis Franklin

Published

2024-04-28

1 The results as an interactive table

2 The results as sensitivity plots

Figure 1: Sensitivity plot of clusters summarised by BMD first quartile

Figure 2: Sensitivity plot of clusters summarised by BMD median with the interquartile range as an interval

3 The top 50 most sensitive clusters

Cluster 46 - 5 transcripts (~ 25% < 1.39 μg/L)

Driver GO terms :

KEGG pathways : Sphingolipid metabolism

Wikipathways :

Figure 3: DR curves for the 1st cluster

Figure 4: BMDplot for the 1st cluster

id	BMD.zSD	TF	trend
b4galt6	38.51	FALSE	dec
cers5	2.59	FALSE	dec
enpp7.1_3.1	0.84	FALSE	U
gba2_1.2	1.39	FALSE	dec
smpd3	49.35	FALSE	dec

Figure 5: Table of the 1st cluster content

Cluster 69 - 3 transcripts (~ 25% < 1.53 μg/L)

Driver GO terms :

KEGG pathways :

Wikipathways :

Figure 6: DR curves for the 2nd cluster

Figure 7: BMDplot for the 2nd cluster

id	BMD.zSD	TF	trend
chia.1	0.3	FALSE	U
hexb_1.3	39.7	FALSE	dec
st3gal7	2.8	FALSE	dec

Figure 8: Table of the 2nd cluster content

Cluster 43 - 9 transcripts (~ 25% < 1.95 μg/L)

Driver GO terms :

KEGG pathways : Retinol metabolism

Wikipathways :

Figure 9: DR curves for the 3rd cluster

Figure 10: BMDplot for the 3rd cluster

id	BMD.zSD	TF	trend
cyp27c1	7.3	FALSE	inc
cyp3c1_1.2	42.0	FALSE	inc
cyp3c3_2.1	1.2	FALSE	U
lrata	37.8	FALSE	inc
lratb.2	1.9	FALSE	inc
ugt1b1_1.2	3.8	FALSE	dec
ugt2a7_2.2	2.5	FALSE	dec
ugt2a7_3.1	1.7	FALSE	dec
zgc:77938	2.9	FALSE	dec

Figure 11: Table of the 3rd cluster content

Cluster 86 - 3 transcripts (~ 25% < 2.34 μg/L)

Driver GO terms :

KEGG pathways :

Wikipathways :

Figure 12: DR curves for the 4th cluster

Figure 13: BMDplot for the 4th cluster

id	BMD.zSD	TF	trend
lims2	4.6	FALSE	inc
parvaa	2.1	FALSE	dec
parvb_1.3	2.6	FALSE	inc

Figure 14: Table of the 4th cluster content

Cluster 10 - 16 transcripts (~ 25% < 2.35 μg/L)

Driver GO terms : sphingolipid metabolic process

KEGG pathways : Sphingolipid metabolism

Wikipathways :

Figure 15: DR curves for the 5th cluster

Figure 16: BMDplot for the 5th cluster

id	BMD.zSD	TF	trend
asah2	1.3	FALSE	dec
atg12_1.2	31.1	FALSE	inc
atg3	2.2	FALSE	U
cers2a_1.2	25.8	FALSE	dec
cers3a_1.2	1.7	FALSE	dec
cers5	2.6	FALSE	dec
kdsr_1.2	2.4	FALSE	dec
pi4kaa	42.3	FALSE	dec
pik3c3_1.2	3.9	FALSE	inc
plpp3	5.3	FALSE	dec
rab5ab	1.7	FALSE	dec
sgpl1_1.1	2.6	FALSE	dec
SPHK1	36.0	FALSE	dec
sphk2	3.6	FALSE	dec
st6galnac4	23.1	FALSE	dec
ugt8_2.1	4.1	FALSE	dec

Figure 17: Table of the 5th cluster content

Cluster 68 - 17 transcripts (~ 25% < 2.36 μg/L)

Driver GO terms :

KEGG pathways : Lysosome

Wikipathways :

Figure 18: DR curves for the 6th cluster

Figure 19: BMDplot for the 6th cluster

id	BMD.zSD	TF	trend
ap3s2_1.3	3.4	FALSE	inc
ap4s1_1.4	35.2	FALSE	inc
cltb	2.8	FALSE	dec
cts12	52.4	FALSE	dec
ctsh	33.8	FALSE	inc
ctss2.2	58.7	FALSE	inc
gga3b	42.6	FALSE	dec
gnptab_1.2	2.3	FALSE	U
gnptg	37.4	FALSE	inc
lgmn_1.2	1.5	FALSE	U
litaf_1.3	43.3	TRUE	inc
mcoln1a	2.8	FALSE	dec
nagpa	1.9	FALSE	dec
pla2g15	2.4	FALSE	dec
ppt1_1.2	45.4	FALSE	inc
ppt2_1.3	2.2	FALSE	bell
slc17a5	3.5	FALSE	dec

Figure 20: Table of the 6th cluster content

Cluster 17 - 28 transcripts (~ 25% < 2.55 μg/L)

Driver GO terms : lipid biosynthetic process

KEGG pathways : Steroid biosynthesis

Wikipathways : Cholesterol biosynthesis

Figure 21: DR curves for the 7th cluster

Figure 22: BMDplot for the 7th cluster

id	BMD.zSD	TF	trend
acsl1b	2.18	FALSE	dec
alox12	3.38	FALSE	dec
cers5	2.59	FALSE	dec
crppa	18.97	FALSE	inc
cyp17a1	2.73	FALSE	dec
cyp27b1	3.01	FALSE	dec
dhcr7	2.41	FALSE	dec
ERG28	41.26	FALSE	dec
fa2h_1.3	1.67	FALSE	dec
fdft1_1.2	1.49	FALSE	dec
fitm1l	27.73	FALSE	inc
gpam	30.83	FALSE	dec
hmgcs1_1.2	2.98	FALSE	dec
impad1	2.66	FALSE	dec
insig2	36.86	FALSE	dec
lss	0.49	FALSE	U
nus1	28.81	FALSE	dec
PYURF_1.1	7.37	FALSE	inc
sc5d	2.28	FALSE	dec
scap	37.09	FALSE	dec
sccpdha.1	1.98	FALSE	dec
scd	23.97	FALSE	inc
si:dkey-205h13.1_1.2	3.42	FALSE	inc
si:dkey-91i10.3	3.26	FALSE	dec
st6galnac4	23.11	FALSE	dec
tamm41	34.60	FALSE	inc
ugt8_2.1	4.12	FALSE	dec
zgc:77375	34.02	FALSE	dec

Figure 23: Table of the 7th cluster content

Cluster 73 - 14 transcripts (~ 25% < 2.96 μg/L)

Driver GO terms : fatty acid transport

KEGG pathways : PPAR signaling pathway

Wikipathways : PPAR signaling pathway

Figure 24: DR curves for the 8th cluster

Figure 25: BMDplot for the 8th cluster

id	BMD.zSD	TF	trend
acox3	3.06	FALSE	dec
acsl1b	2.18	FALSE	dec
CABZ01055347.1	26.93	FALSE	dec
cd36	0.38	FALSE	U
cpt1aa_1.2	2.96	FALSE	dec
cyp8b2	2.21	FALSE	dec
fabp3	38.40	FALSE	inc
fabp7a_1.1	3.60	FALSE	inc
fabp7b	39.95	FALSE	inc
proca1	3.66	FALSE	inc
rbp7b_1.2	17.67	FALSE	inc
scd	23.97	FALSE	inc
si:dkey-91i10.3	3.26	FALSE	dec
slc27a4_1.1	2.98	FALSE	dec

Figure 26: Table of the 8th cluster content

Cluster 76 - 36 transcripts (~ 25% < 2.98 μg/L)

Driver GO terms : intracellular protein transport

KEGG pathways :

Wikipathways :

Figure 27: DR curves for the 9th cluster

Figure 28: BMDplot for the 9th cluster

id	BMD.zSD	TF	trend
ap1b1_1.1	35.91	FALSE	dec
ap1g1	43.08	FALSE	dec
ap1s2_1.2	49.21	FALSE	inc
ap2m1a_1.2	32.77	FALSE	inc
ap2m1a_1.4	2.24	FALSE	dec
ap3s2_1.3	3.43	FALSE	inc
ap4s1_1.4	35.23	FALSE	inc
appbp2	40.08	FALSE	dec
clta_1.3	2.25	FALSE	dec
cltb	2.76	FALSE	dec
copz1	32.50	FALSE	inc
efhc1	4.30	FALSE	bell
erbin_1.4	31.50	TRUE	dec
gga1_2.1	51.01	FALSE	dec
gga3b	42.59	FALSE	dec
kpna1	2.82	FALSE	bell
kpna3	2.48	FALSE	dec
kpna6_1.2	36.86	FALSE	dec
LO017722.1	28.03	FALSE	dec
mon1a	2.03	FALSE	dec
napbb_1.2	36.34	FALSE	dec
pex10	0.63	FALSE	U
pex14_1.2	3.77	TRUE	dec
rab11a	4.30	FALSE	dec
rab1ba	22.42	FALSE	dec
rab5aa	36.94	FALSE	dec
ranbp3b	29.35	FALSE	dec
RIC1	31.81	FALSE	dec
selenos	3.23	FALSE	U
snx27a	26.89	FALSE	dec
strada	2.09	FALSE	inc
STRADB	48.37	FALSE	dec
tgfbrap1	23.45	FALSE	dec
tmed2_1.2	1.76	FALSE	dec
vps37c	32.36	FALSE	dec
zgc:77650_1.1	3.04	FALSE	inc

Figure 29: Table of the 9th cluster content

Cluster 42 - 4 transcripts (~ 25% < 3.01 μg/L)

Driver GO terms :

KEGG pathways :

Wikipathways :

Figure 30: DR curves for the 10th cluster

Figure 31: BMDplot for the 10th cluster

id	BMD.zSD	TF	trend
cbfa2t3_1.2	2.5	FALSE	bell
ldb1b_1.2	31.6	TRUE	dec
lmo1_1.1	3.2	TRUE	inc
tcf3a_1.2	35.7	TRUE	dec

Figure 32: Table of the 10th cluster content

Cluster 30 - 27 transcripts (~ 25% < 3.07 μg/L)

Driver GO terms : myofibril assembly, striated muscle contraction

KEGG pathways : Motor proteins

Wikipathways :

Figure 33: DR curves for the 11th cluster

Figure 34: BMDplot for the 11th cluster

id	BMD.zSD	TF	trend
chchd10_1.2	41.09	FALSE	inc
cx39.9	27.78	FALSE	inc
dctn1a_1.2	35.74	FALSE	dec
dctn4_1.3	4.08	FALSE	bell
dynll2b	3.69	FALSE	inc
erp44	3.03	FALSE	dec
kif1b_1.1	5.11	FALSE	dec
kifc1_1.2	26.20	FALSE	inc
kifc3_1.5	45.08	FALSE	dec
myhz1.1_2.1	2.79	FALSE	inc
myhz1.2_1.2	1.92	FALSE	inc
myhz1.3	4.89	FALSE	inc
myo1b_1.3	2.90	FALSE	dec
MYO1D	4.14	FALSE	dec
prox1a	46.70	TRUE	dec
scn4ba	34.66	FALSE	dec
smyd1b_1.2	34.90	TRUE	inc
tfpi2	3.11	FALSE	inc
thrab_1.2	40.74	TRUE	dec
tnnc2	6.22	FALSE	inc
tnni2a.4_1.2	24.82	FALSE	inc
tnni4b.2	29.69	FALSE	inc
tnnt1_1.2	0.16	FALSE	bell
tnnt1_1.3	51.02	FALSE	inc
tnnt3b_1.4	3.91	FALSE	inc
tnnt3b_1.5	1.94	FALSE	inc
tubb4b_1.2	2.47	FALSE	dec

Figure 35: Table of the 11th cluster content

Cluster 69 - 3 transcripts (~ 25% < 1.53 μg/L)

Driver GO terms :

KEGG pathways :

Wikipathways :

Figure 36: DR curves for the 12th cluster

Figure 37: BMDplot for the 12th cluster

id	BMD.zSD	TF	trend
chia.1	0.3	FALSE	U
hexb_1.3	39.7	FALSE	dec
st3gal7	2.8	FALSE	dec

Figure 38: Table of the 12th cluster content

Cluster 100 - 9 transcripts (~ 25% < 3.19 μg/L)

Driver GO terms : tRNA processing

KEGG pathways :

Wikipathways :

Figure 39: DR curves for the 13th cluster

Figure 40: BMDplot for the 13th cluster

id	BMD.zSD	TF	trend
gtpbp3_1.3	3.2	FALSE	inc
mto1	52.4	FALSE	inc
pop4_2.1	35.8	FALSE	inc
rtcb_1.2	3.9	FALSE	U
thumpd3_2.1	31.2	FALSE	inc
trmt1l_1.2	49.5	FALSE	inc
trmt6	1.9	FALSE	U
trmu	2.3	FALSE	U
tsen2	3.3	FALSE	inc

Figure 41: Table of the 13th cluster content

Cluster 58 - 3 transcripts (~ 25% < 3.31 μg/L)

Driver GO terms :

KEGG pathways :

Wikipathways :

Figure 42: DR curves for the 14th cluster

Figure 43: BMDplot for the 14th cluster

id	BMD.zSD	TF	trend
cdc73_1.2	3.9	TRUE	U
ssrp1b_1.3	2.7	TRUE	inc
supt6h	51.6	TRUE	dec

Figure 44: Table of the 14th cluster content

Cluster 48 - 44 transcripts (~ 25% < 3.34 μg/L)

Driver GO terms :

KEGG pathways : Regulation of actin cytoskeleton, Salmonella infection, Tight junction

Wikipathways :

Figure 45: DR curves for the 15th cluster

Figure 46: BMDplot for the 15th cluster

id	BMD.zSD	TF	trend
abi1b_1.2	49.3	FALSE	dec
acbd3	27.1	FALSE	dec
ACBD3	2.6	FALSE	dec
actb2_1.2	3.8	TRUE	dec
actr2a	4.6	FALSE	dec
actr2b	5.2	FALSE	dec
akt3a_1.2	37.9	FALSE	dec
arf2a_1.1	2.6	FALSE	U
arf2a_1.2	3.0	FALSE	dec
arhgap35a	34.2	TRUE	dec
cldn11a	46.6	FALSE	inc
cldna	2.9	FALSE	dec
cldnk	3.4	FALSE	inc
dctn1a_1.2	35.7	FALSE	dec
dctn4_1.3	4.1	FALSE	bell
dnm2a_1.2	2.2	FALSE	dec
dynll2b	3.7	FALSE	inc
enah_1.2	5.5	FALSE	U
enah_1.3	38.4	FALSE	inc
ezra	3.1	FALSE	dec
ezrb_1.3	4.2	TRUE	dec
fgd1_1.4	39.3	FALSE	dec
fyco1a_1.2	3.9	FALSE	dec
hdr_1.2	2.0	FALSE	dec
hsp90aa1.1	17.7	FALSE	inc
itgb8	49.1	FALSE	dec
jam2a_1.3	38.9	FALSE	inc
kpna1	2.8	FALSE	bell
kpna3	2.5	FALSE	dec
map3k1	5.2	FALSE	dec
mapk14b_1.3	57.9	FALSE	dec
myh9b_1.2	3.6	FALSE	dec
mylkb_1.2	2.9	FALSE	dec
pak4	4.1	FALSE	dec
pak6a	43.7	FALSE	dec
pard6b	7.5	FALSE	dec
ppp2r2bb_1.3	4.7	FALSE	bell
ppp2r2d	21.2	FALSE	dec
rab5aa	36.9	FALSE	dec
tcf7l1a_1.2	34.9	TRUE	dec
tcf7l1b_1.1	5.1	TRUE	dec
tjap1	32.4	FALSE	dec
tubb4b_1.2	2.5	FALSE	dec
zgc:112437	41.2	FALSE	inc

Figure 47: Table of the 15th cluster content

Cluster 59 - 13 transcripts (~ 25% < 3.34 μg/L)

Driver GO terms : nucleotide biosynthetic process

KEGG pathways :

Wikipathways :

Figure 48: DR curves for the 16th cluster

Figure 49: BMDplot for the 16th cluster

id	BMD.zSD	TF	trend
acsl1b	2.2	FALSE	dec
adka_1.2	3.3	FALSE	dec
ak1	6.3	FALSE	inc
ampd3b	3.0	FALSE	dec
atp5f1c	24.5	FALSE	inc
dut	32.5	FALSE	inc
impdh1b_1.2	33.6	FALSE	dec
mt-atp8	34.3	FALSE	inc
nme6	38.5	FALSE	inc
paics_1.1	3.1	FALSE	dec
prtfdc1_1.2	36.6	FALSE	inc
si:ch73-265d7.2	5.1	FALSE	inc
umps	54.2	FALSE	inc

Figure 50: Table of the 16th cluster content

Cluster 16 - 41 transcripts (~ 25% < 3.41 μg/L)

Driver GO terms : organic acid metabolic process

KEGG pathways : 2-Oxocarboxylic acid metabolism, Biosynthesis of amino acids, Carbon metabolism, Citrate cycle (TCA cycle), Glyoxylate and dicarboxylate metabolism

Wikipathways : TCA cycle

Figure 51: DR curves for the 17th cluster

Figure 52: BMDplot for the 17th cluster

id	BMD.zSD	TF	trend
abcd1_1.2	4.7	FALSE	dec
aco1	3.4	FALSE	dec
acox3	3.1	FALSE	dec
acsl1b	2.2	FALSE	dec
acss2l	27.5	FALSE	inc
adi1	28.8	FALSE	inc
aldh1l1_2.1	2.9	FALSE	dec
alox12	3.4	FALSE	dec
asdurf_1.2	40.5	FALSE	inc
aspg_1.3	14.0	FALSE	inc
azin1b	53.0	FALSE	inc
cad_1.2	27.1	FALSE	inc
cpt1aa_1.2	3.0	FALSE	dec
cs	4.6	FALSE	dec
cyp2ad3	33.4	FALSE	inc
cyp2ad6	29.1	FALSE	inc
eno1a_1.2	5.3	FALSE	inc
fa2h_1.3	1.7	FALSE	dec
glulb_1.1	36.3	FALSE	inc
glulb_1.2	30.2	FALSE	inc
gpam	30.8	FALSE	dec
hacl1_1.2	3.5	FALSE	U
hkdc1_2.1	3.1	FALSE	dec
HPDL	28.3	FALSE	inc
idh2	3.7	FALSE	inc
insrb	35.5	FALSE	dec
mdh1aa_1.2	2.8	FALSE	inc
oat_1.2	35.2	FALSE	inc
pa2g4b_1.1	59.1	FALSE	inc
pak1ip1	23.7	FALSE	inc
pdk1	32.3	FALSE	dec
pgk1	36.4	FALSE	inc
phgdh	17.9	FALSE	inc
psat1	9.3	FALSE	inc
pus7_1.3	3.0	FALSE	U
pycr1b	31.6	FALSE	inc
rsl24d1	33.2	FALSE	inc
scd	24.0	FALSE	inc
sdsl	1.2	FALSE	dec
wdr18	27.9	FALSE	inc
znf593	31.1	TRUE	inc

Figure 53: Table of the 17th cluster content

Cluster 67 - 10 transcripts (~ 25% < 3.46 μg/L)

Driver GO terms : amino acid transport

KEGG pathways :

Wikipathways :

Figure 54: DR curves for the 18th cluster

Figure 55: BMDplot for the 18th cluster

id	BMD.zSD	TF	trend
slc1a4_1.2	3.6	FALSE	inc
slc1a8b_1.1	3.4	FALSE	inc
slc25a55b	39.0	FALSE	dec
slc3a2b	3.4	FALSE	inc
slc6a6a	41.3	FALSE	dec
slc7a1a_2.2	3.5	FALSE	dec
slc7a2_2.1	2.4	FALSE	U
slc7a5_2.1	37.8	FALSE	dec
slc7a8a	34.3	FALSE	dec
zgc:158423_2.1	37.7	FALSE	inc

Figure 56: Table of the 18th cluster content

Cluster 39 - 40 transcripts (~ 25% < 3.47 μg/L)

Driver GO terms : carbohydrate metabolic process

KEGG pathways : N-Glycan biosynthesis, Protein processing in endoplasmic reticulum

Wikipathways :

Figure 57: DR curves for the 19th cluster

Figure 58: BMDplot for the 19th cluster

id	BMD.zSD	TF	trend
agla_1.1	3.0	FALSE	dec
atf6	30.3	TRUE	dec
CABZ01079192.1	1.7	FALSE	dec
CR759923.1_1.4	2.2	FALSE	inc
CR774178.2	5.1	FALSE	dec
dnajb11	2.9	FALSE	dec
dnajc1	33.8	TRUE	inc
dnajc5aa	39.5	FALSE	dec
eif2s1b	34.6	FALSE	inc
eno1a_1.2	5.3	FALSE	inc
ganab	34.4	FALSE	dec
GANAB_1.2	2.6	FALSE	dec
gcgra_2.1	3.5	FALSE	dec
hexa_1.1	30.8	FALSE	dec
hkdc1_2.1	3.1	FALSE	dec
hsp70.1_1.2	52.7	FALSE	inc
hsp70l	68.6	FALSE	inc
hsp90aa1.1	17.7	FALSE	inc
hspa1b	20.5	TRUE	inc
hsph1	4.3	FALSE	inc
insrb	35.5	FALSE	dec
kctd10	4.7	FALSE	U
lancl1	1.9	FALSE	inc
man1a1	36.4	FALSE	dec
man1b1b	36.7	FALSE	dec
MAN1C1_1.2	29.0	FALSE	dec
man2a1	3.1	FALSE	dec
march6_1.2	39.1	FALSE	dec
mgat5	35.6	FALSE	dec
myorg	3.3	FALSE	dec
pdia6	5.5	FALSE	dec
pdk1	32.3	FALSE	dec
pgk1	36.4	FALSE	inc
rnf185_1.2	28.7	FALSE	inc
RNF5	31.9	FALSE	dec
selenos	3.2	FALSE	U
spata20	27.8	FALSE	inc
srd5a3	25.2	FALSE	inc
st6galnac4	23.1	FALSE	dec
xbp1_1.2	48.4	TRUE	inc

Figure 59: Table of the 19th cluster content

Cluster 89 - 6 transcripts (~ 25% < 3.71 μg/L)

Driver GO terms :

KEGG pathways : Arachidonic acid metabolism

Wikipathways :

Figure 60: DR curves for the 20th cluster

Figure 61: BMDplot for the 20th cluster

id	BMD.zSD	TF	trend
alox12	3.4	FALSE	dec
gpx4b	22.6	FALSE	inc
proca1	3.7	FALSE	inc
prxl2b_1.2	3.9	FALSE	dec
ptgdsb.2	41.7	FALSE	inc
ptges3b	46.2	FALSE	inc

Figure 62: Table of the 20th cluster content

Cluster 8 - 56 transcripts (~ 25% < 3.74 μg/L)

Driver GO terms : generation of precursor metabolites and energy, muscle system process

KEGG pathways : Cardiac muscle contraction, Oxidative phosphorylation, Vascular smooth muscle contraction

Wikipathways : Electron transport chain, Oxidative phosphorylation

Figure 63: DR curves for the 21st cluster

Figure 64: BMDplot for the 21st cluster

id	BMD.zSD	TF	trend
adma	38.2	FALSE	inc
agla_1.1	3.0	FALSE	dec
atp1a3a	58.6	FALSE	dec
atp2a1_1.1	43.0	FALSE	inc
atp2a2b	3.3	FALSE	dec
atp2a3_1.3	2.8	FALSE	dec
atp5f1c	24.5	FALSE	inc
BX936363.1	33.6	FALSE	dec
cacng1a	30.6	FALSE	inc
cald1a	4.6	FALSE	dec
cald1b_1.2	23.7	FALSE	dec
coa6	4.6	FALSE	inc
cox11_1.2	32.8	FALSE	inc
cox7a2a_1.2	38.4	FALSE	inc
cx39.9	27.8	FALSE	inc
eno1a_1.2	5.3	FALSE	inc
erp44	3.0	FALSE	dec
foxo3b	39.2	TRUE	dec
gna11b	39.7	FALSE	dec
gnas_1.2	34.9	FALSE	dec
hkdc1_2.1	3.1	FALSE	dec
htr1d	2.7	FALSE	inc
insrb	35.5	FALSE	dec
lamtor3	33.8	FALSE	inc
lsp1a	4.3	FALSE	dec
mapk3	24.9	FALSE	dec
mt-atp6	3.5	FALSE	inc
mt-atp8	34.3	FALSE	inc
mt-co1	3.8	FALSE	inc
mt-co2	5.5	FALSE	inc
mt-co3	3.6	FALSE	inc
mt-cyb	3.7	FALSE	inc
mt-nd2	5.3	FALSE	inc
myhz1.1_2.1	2.8	FALSE	inc
myhz1.3	4.9	FALSE	inc
mylkb_1.2	2.9	FALSE	dec
mylpfa_1.2	4.6	FALSE	inc
oxct1a_1.2	3.2	FALSE	inc
pgk1	36.4	FALSE	inc
ppa1b	29.1	FALSE	inc
proca1	3.7	FALSE	inc
rock2a_1.2	3.6	FALSE	U
scn4ba	34.7	FALSE	dec
sco1_1.1	44.6	FALSE	inc
sdhb	40.8	FALSE	inc
sdhc_1.2	29.1	FALSE	inc
si:ch211-139a5.9_1.1	29.7	FALSE	inc
si:ch73-265d7.2	5.1	FALSE	inc
slc25a55b	39.0	FALSE	dec
slc8a2b	47.0	FALSE	dec
soul4	49.9	FALSE	dec
stmn1a_1.2	33.9	FALSE	inc
stmn1a_1.3	21.2	FALSE	inc
surf1	35.7	FALSE	inc
trdn_1.4	57.1	FALSE	dec
ucp2	53.2	FALSE	inc

Figure 65: Table of the 21st cluster content

Cluster 14 - 25 transcripts (~ 25% < 3.75 μg/L)

Driver GO terms : protein folding

KEGG pathways :

Wikipathways :

Figure 66: DR curves for the 22nd cluster

Figure 67: BMDplot for the 22nd cluster

id	BMD.zSD	TF	trend
ahsa1a_1.3	4.5	FALSE	inc
CABZ01080568.1	17.8	FALSE	inc
cct2_1.1	6.8	FALSE	inc
cct3	36.1	FALSE	inc
cct4	36.4	FALSE	inc
cct5	38.4	FALSE	inc
cct6a_1.3	37.5	FALSE	inc
cct7	49.6	FALSE	inc
cct8_1.2	3.1	FALSE	inc
cryaa_2.1	30.1	FALSE	dec
dnajb11	2.9	FALSE	dec
dnajc18	3.8	FALSE	inc
dnajc5aa	39.5	FALSE	dec
erp44	3.0	FALSE	dec
hsp70.1_1.2	52.7	FALSE	inc
hsp90aa1.1	17.7	FALSE	inc
hspa8_2.1	51.2	FALSE	inc
p4hb_1.1	2.2	FALSE	dec
pfdn5_2.1	40.9	FALSE	inc
ppiaa	27.2	FALSE	inc
ppid_1.2	25.1	TRUE	inc
si:ch211-131k2.3	18.5	FALSE	inc
st13	2.8	FALSE	dec
tor1_1.2	2.5	FALSE	dec
wdr83os_1.1	25.3	FALSE	inc

Figure 68: Table of the 22nd cluster content

Cluster 90 - 21 transcripts (~ 25% < 3.75 μg/L)

Driver GO terms : protein folding

KEGG pathways :

Wikipathways :

Figure 69: DR curves for the 23rd cluster

Figure 70: BMDplot for the 23rd cluster

id	BMD.zSD	TF	trend
ahsa1a_1.3	4.5	FALSE	inc
CABZ01080568.1	17.8	FALSE	inc
cryaa_2.1	30.1	FALSE	dec
dnajb11	2.9	FALSE	dec
dnajc18	3.8	FALSE	inc
dnajc5aa	39.5	FALSE	dec
erp44	3.0	FALSE	dec
hsp70.1_1.2	52.7	FALSE	inc
hsp90aa1.1	17.7	FALSE	inc
hspa8_2.1	51.2	FALSE	inc
p4hb_1.1	2.2	FALSE	dec
pfdn2	32.1	FALSE	inc
pfdn4	41.3	FALSE	inc
pfdn5_2.1	40.9	FALSE	inc
pfdn5_3.1	28.0	TRUE	inc
ppiaa	27.2	FALSE	inc
ppid_1.2	25.1	TRUE	inc
si:ch211-131k2.3	18.5	FALSE	inc
st13	2.8	FALSE	dec
tor1_1.2	2.5	FALSE	dec
wdr83os_1.1	25.3	FALSE	inc

Figure 71: Table of the 23rd cluster content

Cluster 44 - 38 transcripts (~ 25% < 3.78 μg/L)

Driver GO terms : canonical NF-kappaB signal transduction

KEGG pathways : Apoptosis, C-type lectin receptor signaling pathway, MAPK signaling pathway

Wikipathways :

Figure 72: DR curves for the 24th cluster

Figure 73: BMDplot for the 24th cluster

id	BMD.zSD	TF	trend
akt3a_1.2	37.91	FALSE	dec
apaf1_1.2	0.42	FALSE	U
arf2b_1.2	3.69	FALSE	dec
cacng1a	30.61	FALSE	inc
cts12	52.43	FALSE	dec
ctsh	33.75	FALSE	inc
ctss2.2	58.70	FALSE	inc
cylda_1.2	2.29	FALSE	inc
eif2s1b	34.59	FALSE	inc
hdr_1.2	2.03	FALSE	dec
hsp70.1_1.2	52.68	FALSE	inc
hsp70l	68.64	FALSE	inc
hspa1b	20.47	TRUE	inc
ikbkg_1.1	2.06	TRUE	dec
ikbkg_1.2	2.42	TRUE	bell
insrb	35.55	FALSE	dec
irf2a_1.2	3.10	TRUE	inc
irf7_1.2	23.10	TRUE	inc
jund	42.72	TRUE	dec
ksr1b_1.4	37.30	FALSE	inc
lmnb2	20.38	FALSE	dec
map3k1	5.24	FALSE	dec
map3k14a	35.23	FALSE	inc
map4k6	0.79	FALSE	bell
mapk14b_1.3	57.92	FALSE	dec
mcl1a	24.25	FALSE	inc
mef2cb_1.5	41.30	TRUE	dec
mtdha_1.2	1.63	FALSE	dec
n4bp1	31.11	FALSE	dec
plcg2_1.2	4.02	FALSE	dec
ppm1ba	32.96	FALSE	dec
ppm1bb	28.92	FALSE	dec
ptpn13_1.5	0.84	FALSE	dec
rps6ka2	4.53	FALSE	bell
s100b	27.44	FALSE	inc
scaf11_1.1	37.16	FALSE	dec
taok1a_1.2	39.92	FALSE	dec
taok2b	39.79	FALSE	dec

Figure 74: Table of the 24th cluster content

Cluster 63 - 31 transcripts (~ 25% < 3.78 μg/L)

Driver GO terms : glucan metabolic process

KEGG pathways : Calcium signaling pathway, Insulin signaling pathway

Wikipathways :

Figure 75: DR curves for the 25th cluster

Figure 76: BMDplot for the 25th cluster

id	BMD.zSD	TF	trend
agla_1.1	3.0	FALSE	dec
akt3a_1.2	37.9	FALSE	dec
atp2a1_1.1	43.0	FALSE	inc
atp2a2b	3.3	FALSE	dec
atp2a3_1.3	2.8	FALSE	dec
atp2b1a	40.6	FALSE	dec
camk1b	5.7	FALSE	dec
cbl	41.4	TRUE	dec
eif4e2	4.8	FALSE	inc
gna11b	39.7	FALSE	dec
gnas_1.2	34.9	FALSE	dec
grin1b_1.1	1.8	FALSE	inc
insrb	35.5	FALSE	dec
irs1	27.5	FALSE	dec
mcoln1a	2.8	FALSE	dec
MCOLN3_1.3	2.7	FALSE	dec
mcu	4.7	FALSE	dec
mylkb_1.2	2.9	FALSE	dec
pde3b	33.0	FALSE	dec
phkb_1.4	4.6	FALSE	inc
phkg1b_1.2	42.1	FALSE	inc
phkg2	4.6	FALSE	U
plcg1_1.1	34.3	FALSE	dec
plcg1_1.2	39.7	FALSE	dec
plcg2_1.2	4.0	FALSE	dec
ppargc1a	37.8	TRUE	dec
ppp1r3cb_1.2	39.4	FALSE	inc
slc8a2b	47.0	FALSE	dec
stim1a_1.3	41.2	FALSE	dec
trdn_1.4	57.1	FALSE	dec
vdac3_1.1	3.5	FALSE	inc

Figure 77: Table of the 25th cluster content

Cluster 83 - 16 transcripts (~ 25% < 3.83 μg/L)

Driver GO terms : Notch signaling pathway

KEGG pathways : Notch signaling pathway

Wikipathways :

Figure 78: DR curves for the 26th cluster

Figure 79: BMDplot for the 26th cluster

id	BMD.zSD	TF	trend
chsy1	43.3	FALSE	dec
dlb	4.1	FALSE	inc
dtx4a	47.1	FALSE	dec
egfl6_1.1	39.9	FALSE	inc
gmds_1.1	5.8	FALSE	dec
gmds_1.3	3.1	FALSE	dec
itcha	47.8	FALSE	dec
itchb	39.3	TRUE	dec
lfng_1.2	24.1	FALSE	inc
notch1a_1.2	2.3	TRUE	inc
notch1b_1.3	48.6	FALSE	dec
plvapb	57.5	FALSE	inc
psen2	1.9	FALSE	dec
tcima	31.7	FALSE	inc
tet3_1.2	43.3	FALSE	dec
tet3_1.3	2.3	FALSE	inc

Figure 80: Table of the 26th cluster content

Cluster 70 - 35 transcripts (~ 25% < 3.89 μg/L)

Driver GO terms : canonical Wnt signaling pathway

KEGG pathways : mTOR signaling pathway, Wnt signaling pathway

Wikipathways :

Figure 81: DR curves for the 27th cluster

Figure 82: BMDplot for the 27th cluster

id	BMD.zSD	TF	trend
akt3a_1.2	37.9	FALSE	dec
bcl9_1.2	45.0	TRUE	dec
cacybp	27.0	FALSE	inc
csnk1g2a_1.2	30.3	FALSE	dec
cylda_1.2	2.3	FALSE	inc
daam1a_1.2	51.7	FALSE	dec
depdc5_1.1	3.9	FALSE	inc
dot1l_1.3	47.2	FALSE	dec
eif4e2	4.8	FALSE	inc
fzd1	2.6	FALSE	U
fzd10	42.4	FALSE	inc
grb10a	3.5	FALSE	dec
gskip	3.9	FALSE	dec
insrb	35.5	FALSE	dec
irs1	27.5	FALSE	dec
lrp5_1.2	4.4	FALSE	dec
mapkap1_1.2	19.0	FALSE	dec
ppm1ba	33.0	FALSE	dec
ppm1bb	28.9	FALSE	dec
rnf146_1.2	16.9	FALSE	dec
rps6ka2	4.5	FALSE	bell
sgk2b_1.2	2.3	FALSE	inc
si:ch211-195b13.1_1.2	5.5	FALSE	inc
si:dkey-1c11.1_1.2	1.7	FALSE	inc
si:dkey-222b8.1_2.1	30.3	TRUE	dec
strada	2.1	FALSE	inc
STRADB	48.4	FALSE	dec
tcf7l1a_1.2	34.9	TRUE	dec
tcf7l1b_1.1	5.1	TRUE	dec
tcf7l2_1.10	42.3	TRUE	dec
tet3_1.2	43.3	FALSE	dec
tet3_1.3	2.3	FALSE	inc
tti1	27.0	FALSE	inc
vangl2	36.5	FALSE	dec
wnt4b_2.1	1.4	FALSE	bell

Figure 83: Table of the 27th cluster content

Cluster 41 - 45 transcripts (~ 25% < 3.92 μg/L)

Driver GO terms : mRNA processing

KEGG pathways : mRNA surveillance pathway

Wikipathways : mRNA processing

Figure 84: DR curves for the 28th cluster

Figure 85: BMDplot for the 28th cluster

id	BMD.zSD	TF	trend
celf2_1.2	32.7	FALSE	dec
celf2_1.4	27.6	FALSE	dec
clk2a_1.1	7.0	FALSE	dec
cpsf3	57.2	FALSE	inc
cpsf6_1.2	2.1	FALSE	dec
cstf2_1.2	3.7	FALSE	inc
ern1	60.3	TRUE	dec
hnrnpa1b_1.2	2.2	FALSE	inc
hnrnpaba_1.3	7.9	FALSE	dec
hnrnpk_1.3	59.0	FALSE	dec
hnrnpm_1.3	2.0	FALSE	bell
hnrnpm_1.4	33.9	FALSE	dec
hnrnpua	45.0	FALSE	dec
msi2b_1.6	4.1	FALSE	inc
msi2b_1.8	38.4	FALSE	dec
pabpn1_1.1	4.6	FALSE	inc
pabpn1_1.3	28.7	FALSE	dec
papolg	2.3	FALSE	bell
pcbp4_1.1	2.5	FALSE	dec
ppp2r2bb_1.3	4.7	FALSE	bell
ppp2r2d	21.2	FALSE	dec
ppp2r3c	26.2	FALSE	inc
ptbp3	20.6	FALSE	dec
puf60a_1.3	3.5	TRUE	inc
qkia_1.2	32.5	FALSE	dec
rbm15_2.1	35.7	TRUE	dec
rbm26_1.2	32.0	FALSE	dec
rbm27	33.7	FALSE	dec
rbm39a_1.4	1.4	TRUE	dec
rbm39a_1.5	3.9	TRUE	inc
rbm39b_1.1	5.1	FALSE	inc
rbm4.2	1.8	FALSE	bell
rbm4.3	24.1	FALSE	dec
rbm5_1.2	36.6	FALSE	dec
sf1_1.2	41.2	FALSE	dec
smndc1_1.1	51.3	FALSE	inc
smx5	29.4	FALSE	inc
snrnp25	29.2	FALSE	inc
snu13b	40.3	FALSE	inc
srsf3b_1.1	52.5	FALSE	dec
srsf5b_1.1	3.2	FALSE	bell
taf15_1.1	1.4	FALSE	dec
thoc7	32.7	FALSE	inc
tssc4_1.2	4.8	FALSE	inc
xrn2_1.2	28.1	TRUE	dec

Figure 86: Table of the 28th cluster content

Cluster 13 - 62 transcripts (~ 25% < 3.99 μg/L)

Driver GO terms : translational initiation, RNA splicing

KEGG pathways : Herpes simplex virus 1 infection, Spliceosome

Wikipathways :

Figure 87: DR curves for the 29th cluster

Figure 88: BMDplot for the 29th cluster

id	BMD.zSD	TF	trend
akt3a_1.2	37.91	FALSE	dec
apaf1_1.2	0.42	FALSE	U
cdc123_1.2	34.85	FALSE	inc
clk2a_1.1	6.97	FALSE	dec
ddx5_1.1	2.49	TRUE	dec
ddx5_1.4	4.00	TRUE	inc
eif2b1_1.2	25.74	FALSE	inc
eif2b3_1.2	37.46	FALSE	inc
eif2b4_1.2	25.39	FALSE	inc
eif2b5	39.41	FALSE	inc
eif2s1b	34.59	FALSE	inc
eif2s2	40.56	FALSE	inc
eif2s3_1.3	29.30	FALSE	inc
eif4e2	4.77	FALSE	inc
eif4ebp2	3.35	FALSE	dec
eif4enif1_1.3	32.65	FALSE	dec
hmga1a_1.1	3.64	TRUE	dec
hmga1a_1.2	2.80	TRUE	dec
hmga1a_1.3	4.91	TRUE	inc
hnrnpa1b_1.2	2.18	FALSE	inc
hnrnpk_1.3	58.96	FALSE	dec
hnrnpm_1.3	1.98	FALSE	bell
hnrnpm_1.4	33.91	FALSE	dec
hnrnpua	45.03	FALSE	dec
hsp70.1_1.2	52.68	FALSE	inc
hsp70l	68.64	FALSE	inc
hspa1b	20.47	TRUE	inc
irf7_1.2	23.10	TRUE	inc
mbnl1_1.5	53.83	FALSE	inc
pcbp4_1.1	2.54	FALSE	dec
ppil1	34.72	FALSE	inc
prpf18_1.2	45.14	FALSE	dec
ptbp3	20.62	FALSE	dec
puf60a_1.3	3.49	TRUE	inc
qkia_1.2	32.51	FALSE	dec
rbfox1_1.1	47.48	TRUE	dec
rbfox1_1.5	38.16	TRUE	dec
rbfox1l_1.1	35.52	FALSE	inc
rbfox1l_2.1	31.90	FALSE	inc
rbm15_2.1	35.69	TRUE	dec
rbm4.2	1.85	FALSE	bell
rbm4.3	24.11	FALSE	dec
rbm5_1.2	36.59	FALSE	dec
rp9_1.3	3.20	FALSE	inc
rtcb_1.2	3.90	FALSE	U
sf1_1.2	41.23	FALSE	dec
si:dkey-67c22.2_1.2	27.80	FALSE	dec
slu7_1.2	3.98	FALSE	dec
snrnp25	29.23	FALSE	inc
snrnp27	42.56	FALSE	inc
snu13b	40.27	FALSE	inc
srsf3b_1.1	52.54	FALSE	dec
srsf5b_1.1	3.25	FALSE	bell
taf15_1.1	1.39	FALSE	dec
tapbp.1	35.67	FALSE	inc
thoc1	32.02	FALSE	inc
thrap3b_1.4	46.33	FALSE	dec
thrap3b_1.5	35.74	FALSE	dec
tsen2	3.34	FALSE	inc
tssc4_1.2	4.85	FALSE	inc
wbp11_1.1	33.15	FALSE	dec
zgc:55733_1.2	33.64	TRUE	inc

Figure 89: Table of the 29th cluster content

Cluster 54 - 16 transcripts (~ 25% < 4.02 μg/L)

Driver GO terms :

KEGG pathways : Tight junction

Wikipathways :

Figure 90: DR curves for the 30th cluster

Figure 91: BMDplot for the 30th cluster

id	BMD.zSD	TF	trend
cldn11a	46.6	FALSE	inc
cldna	2.9	FALSE	dec
cldnk	3.4	FALSE	inc
dlg1l_1.3	32.7	FALSE	dec
dlg1l_1.4	4.1	FALSE	dec
ezra	3.1	FALSE	dec
ezrb_1.3	4.2	TRUE	dec
jam2a_1.3	38.9	FALSE	inc
llgl2_1.3	3.9	FALSE	dec
map3k1	5.2	FALSE	dec
pard6b	7.5	FALSE	dec
ppp2r2bb_1.3	4.7	FALSE	bell
ppp2r2d	21.2	FALSE	dec
scrib_1.3	38.3	FALSE	dec
tjap1	32.4	FALSE	dec
zgc:112437	41.2	FALSE	inc

Figure 92: Table of the 30th cluster content

Cluster 87 - 3 transcripts (~ 25% < 4.2 μg/L)

Driver GO terms :

KEGG pathways :

Wikipathways :

Figure 93: DR curves for the 31st cluster

Figure 94: BMDplot for the 31st cluster

id	BMD.zSD	TF	trend
ift52	5.4	FALSE	inc
ttc26	3.0	FALSE	inc
zgc:158640	32.8	FALSE	inc

Figure 95: Table of the 31st cluster content

Cluster 97 - 20 transcripts (~ 25% < 4.25 μg/L)

Driver GO terms :

KEGG pathways : Protein processing in endoplasmic reticulum

Wikipathways :

Figure 96: DR curves for the 32nd cluster

Figure 97: BMDplot for the 32nd cluster

id	BMD.zSD	TF	trend
atf6	30.3	TRUE	dec
calr3b	4.1	FALSE	dec
canx	4.1	FALSE	dec
dnajb11	2.9	FALSE	dec
dnajc1	33.8	TRUE	inc
dnajc5aa	39.5	FALSE	dec
eif2s1b	34.6	FALSE	inc
ganab	34.4	FALSE	dec
hsp70.1_1.2	52.7	FALSE	inc
hsp70l	68.6	FALSE	inc
hsp90aa1.1	17.7	FALSE	inc
hspa1b	20.5	TRUE	inc
hsph1	4.3	FALSE	inc
march6_1.2	39.1	FALSE	dec
pdia3_1.2	3.0	FALSE	dec
pdia6	5.5	FALSE	dec
rnf185_1.2	28.7	FALSE	inc
RNF5	31.9	FALSE	dec
selenos	3.2	FALSE	U
xbp1_1.2	48.4	TRUE	inc

Figure 98: Table of the 32nd cluster content

Cluster 12 - 70 transcripts (~ 25% < 4.37 μg/L)

Driver GO terms : RNA splicing, via transesterification reactions

KEGG pathways : Adherens junction, Mitophagy - animal, Ribosome biogenesis in eukaryotes, Wnt signaling pathway, Spliceosome

Wikipathways :

Figure 99: DR curves for the 33rd cluster

Figure 100: BMDplot for the 33rd cluster

id	BMD.zSD	TF	trend
acp1_1.1	32.6	FALSE	inc
atg9a_1.4	43.4	FALSE	inc
bcl9_1.2	45.0	TRUE	dec
cacybp	27.0	FALSE	inc
cdh1_1.2	4.4	FALSE	dec
csnk1g2a_1.2	30.3	FALSE	dec
csnk2a2a	4.6	FALSE	inc
csnk2a4	1.0	FALSE	U
ctnnb1_1.1	32.8	TRUE	dec
cylda_1.2	2.3	FALSE	inc
daam1a_1.2	51.7	FALSE	dec
dot1l_1.3	47.2	FALSE	dec
eif2s1b	34.6	FALSE	inc
farp2_1.2	9.1	FALSE	U
grb10a	3.5	FALSE	dec
gsk3ba	22.3	TRUE	dec
gskip	3.9	FALSE	dec
hnrnpa1b_1.2	2.2	FALSE	inc
hnrnpk_1.3	59.0	FALSE	dec
hnrnpm_1.3	2.0	FALSE	bell
hnrnpm_1.4	33.9	FALSE	dec
hnrnpua	45.0	FALSE	dec
hsp70.1_1.2	52.7	FALSE	inc
hsp70l	68.6	FALSE	inc
hspa1b	20.5	TRUE	inc
insrb	35.5	FALSE	dec
LSM2_1.4	3.2	FALSE	dec
lsm5_1.2	4.4	FALSE	inc
mon1a	2.0	FALSE	dec
nmd3	48.1	FALSE	inc
pcbp4_1.1	2.5	FALSE	dec
ppm1ba	33.0	FALSE	dec
ppm1bb	28.9	FALSE	dec
puf60a_1.3	3.5	TRUE	inc
rab5aa	36.9	FALSE	dec
ran	30.5	TRUE	inc
rbm15_2.1	35.7	TRUE	dec
rbm4.2	1.8	FALSE	bell
rbm4.3	24.1	FALSE	dec
rbm5_1.2	36.6	FALSE	dec
rnf146_1.2	16.9	FALSE	dec
rp9_1.3	3.2	FALSE	inc
sf1_1.2	41.2	FALSE	dec
sf3b6	32.7	FALSE	inc
si:dkey-1c11.1_1.2	1.7	FALSE	inc
si:dkey-222b8.1_2.1	30.3	TRUE	dec
snrnp25	29.2	FALSE	inc
snrnp27	42.6	FALSE	inc
snrpd2	57.0	FALSE	inc
snrpg	40.8	FALSE	inc
snu13b	40.3	FALSE	inc
srsf3b_1.1	52.5	FALSE	dec
srsf5b_1.1	3.2	FALSE	bell
taf15_1.1	1.4	FALSE	dec
tbl1xr1b	4.7	FALSE	dec
tcf7l1a_1.2	34.9	TRUE	dec
tcf7l1b_1.1	5.1	TRUE	dec
tcf7l2_1.10	42.3	TRUE	dec
tet3_1.2	43.3	FALSE	dec
tet3_1.3	2.3	FALSE	inc
thoc1	32.0	FALSE	inc
usp8	31.4	FALSE	dec
UTP14C	52.0	FALSE	dec
vangl2	36.5	FALSE	dec
wbp11_1.1	33.1	FALSE	dec
wnt4b_2.1	1.4	FALSE	bell
xrn1	35.5	FALSE	dec
xrn2_1.2	28.1	TRUE	dec
zgc:55733_1.2	33.6	TRUE	inc
zgc:86598_1.2	27.0	TRUE	inc

Figure 101: Table of the 33rd cluster content

Cluster 75 - 10 transcripts (~ 25% < 4.67 μg/L)

Driver GO terms : phospholipid biosynthetic process

KEGG pathways :

Wikipathways :

Figure 102: DR curves for the 34th cluster

Figure 103: BMDplot for the 34th cluster

id	BMD.zSD	TF	trend
fitm1l	27.7	FALSE	inc
gpam	30.8	FALSE	dec
impad1	2.7	FALSE	dec
pisd_2.1	57.1	FALSE	dec
ptdss2_1.2	22.7	FALSE	dec
PYURF_1.1	7.4	FALSE	inc
selenoi	3.8	FALSE	dec
si:dkey-205h13.1_1.2	3.4	FALSE	inc
tamm41	34.6	FALSE	inc
zgc:77375	34.0	FALSE	dec

Figure 104: Table of the 34th cluster content

Cluster 9 - 19 transcripts (~ 25% < 4.71 μg/L)

Driver GO terms : transcription by RNA polymerase I, transcription by RNA polymerase III, translational initiation

KEGG pathways : Cytosolic DNA-sensing pathway, RNA polymerase

Wikipathways :

Figure 105: DR curves for the 35th cluster

Figure 106: BMDplot for the 35th cluster

id	BMD.zSD	TF	trend
eif2s1b	34.6	FALSE	inc
eif4a2_1.2	4.2	FALSE	inc
eif4ba_1.4	41.6	FALSE	dec
eif4bb_1.3	4.0	FALSE	dec
eif4e2	4.8	FALSE	inc
eif4ea_1.1	45.9	FALSE	dec
eif4ebp2	3.4	FALSE	dec
eif4enif1_1.3	32.6	FALSE	dec
eif4g1a_1.3	4.6	FALSE	U
irf7_1.2	23.1	TRUE	inc
polr1c_1.2	40.8	FALSE	inc
polr2c_2.1	30.7	FALSE	inc
polr2eb	52.3	FALSE	inc
polr2f_1.1	3.7	FALSE	dec
polr2h	29.8	FALSE	inc
polr2l	41.7	FALSE	inc
polr3k	26.9	FALSE	inc
rrn3_1.2	37.6	TRUE	inc
snapc1b	49.1	FALSE	inc

Figure 107: Table of the 35th cluster content

Cluster 80 - 5 transcripts (~ 25% < 4.75 μg/L)

Driver GO terms : iron-sulfur cluster assembly

KEGG pathways :

Wikipathways :

Figure 108: DR curves for the 36th cluster

Figure 109: BMDplot for the 36th cluster

id	BMD.zSD	TF	trend
ciao1	3.9	FALSE	U
isca1	25.8	FALSE	inc
isca2_1.2	4.8	FALSE	inc
ISCU	37.5	FALSE	inc
zgc:110319_1.2	37.9	FALSE	inc

Figure 110: Table of the 36th cluster content

Cluster 33 - 13 transcripts (~ 25% < 4.81 μg/L)

Driver GO terms :

KEGG pathways : ATP-dependent chromatin remodeling

Wikipathways :

Figure 111: DR curves for the 37th cluster

Figure 112: BMDplot for the 37th cluster

id	BMD.zSD	TF	trend
actr8	44.5	TRUE	inc
brd8_1.3	6.9	FALSE	dec
brd8_1.4	4.2	FALSE	inc
chaf1a_2.2	4.8	FALSE	dec
chd3_2.2	30.4	TRUE	dec
chrac1_1.2	25.0	TRUE	inc
ep400_1.2	3.4	TRUE	inc
gatad2b	24.9	TRUE	dec
h2ax	28.1	FALSE	inc
lin52_1.2	44.3	FALSE	inc
rbbp4	36.7	TRUE	inc
smarcb1b_1.3	2.9	FALSE	inc
yeats4	48.8	TRUE	inc

Figure 113: Table of the 37th cluster content

Cluster 94 - 3 transcripts (~ 25% < 5.06 μg/L)

Driver GO terms : microtubule nucleation

KEGG pathways :

Wikipathways :

Figure 114: DR curves for the 38th cluster

Figure 115: BMDplot for the 38th cluster

id	BMD.zSD	TF	trend
tubgcp2	35.0	FALSE	inc
tubgcp4	3.4	FALSE	inc
tubgcp5	6.7	FALSE	inc

Figure 116: Table of the 38th cluster content

Cluster 5 - 44 transcripts (~ 25% < 5.22 μg/L)

Driver GO terms : protein catabolic process

KEGG pathways : Proteasome

Wikipathways :

Figure 117: DR curves for the 39th cluster

Figure 118: BMDplot for the 39th cluster

id	BMD.zSD	TF	trend
anapc4_1.2	4.7	FALSE	inc
appbp2	40.1	FALSE	dec
arih2_1.1	2.7	FALSE	dec
azin1b	53.0	FALSE	inc
CR788324.2	33.2	FALSE	dec
cylda_1.2	2.3	FALSE	inc
desi1a	5.3	FALSE	inc
fbxo33	37.8	FALSE	dec
hectd3_1.2	2.7	FALSE	dec
itcha	47.8	FALSE	dec
itchb	39.3	TRUE	dec
kctd10	4.7	FALSE	U
kctd5a	25.2	FALSE	dec
lgmn_1.2	1.5	FALSE	U
pomp	37.3	FALSE	inc
ppt1_1.2	45.4	FALSE	inc
psma3	36.2	FALSE	inc
psma4	39.1	FALSE	inc
psma5_1.1	33.1	FALSE	inc
psma6b_1.2	45.4	FALSE	inc
psmb4	47.0	FALSE	inc
psmc1a_2.2	42.8	FALSE	inc
psmc4_1.2	38.8	FALSE	inc
psmd12	51.7	FALSE	inc
psmd13	39.2	FALSE	inc
psmd14	42.2	FALSE	inc
psmd2	5.1	FALSE	dec
psmd4a_1.2	47.9	FALSE	inc
psme3_1.2	47.1	FALSE	inc
psme4b_2.2	1.2	FALSE	bell
rnf146_1.2	16.9	FALSE	dec
uba7	1.8	FALSE	U
ube2a_1.2	4.9	FALSE	inc
ube2al	38.9	FALSE	inc
usp1_1.2	23.8	FALSE	inc
usp14	36.2	FALSE	inc
usp24_1.2	35.4	FALSE	dec
usp2a_1.4	38.0	FALSE	dec
usp2a_1.5	3.8	FALSE	inc
usp32	34.3	FALSE	dec
usp4	45.4	FALSE	dec
usp48_1.2	37.7	FALSE	inc
usp8	31.4	FALSE	dec
vps37c	32.4	FALSE	dec

Figure 119: Table of the 39th cluster content

Cluster 31 - 25 transcripts (~ 25% < 5.53 μg/L)

Driver GO terms :

KEGG pathways : Protein export, Protein processing in endoplasmic reticulum

Wikipathways :

Figure 120: DR curves for the 40th cluster

Figure 121: BMDplot for the 40th cluster

id	BMD.zSD	TF	trend
atf6	30.3	TRUE	dec
dnajb11	2.9	FALSE	dec
dnajc1	33.8	TRUE	inc
dnajc5aa	39.5	FALSE	dec
eif2s1b	34.6	FALSE	inc
ganab	34.4	FALSE	dec
hsp70.1_1.2	52.7	FALSE	inc
hsp70l	68.6	FALSE	inc
hsp90aa1.1	17.7	FALSE	inc
hspa1b	20.5	TRUE	inc
hsph1	4.3	FALSE	inc
march6_1.2	39.1	FALSE	dec
pdia6	5.5	FALSE	dec
rnf185_1.2	28.7	FALSE	inc
RNF5	31.9	FALSE	dec
sec61b_1.2	3.2	FALSE	dec
sec61g	49.9	FALSE	inc
sec62	42.1	FALSE	dec
sec63	5.3	FALSE	dec
selenos	3.2	FALSE	U
sgta_1.2	39.5	FALSE	inc
spcs2_1.2	5.5	FALSE	dec
spcs3_1.2	38.9	FALSE	inc
ssr2_1.2	2.8	FALSE	dec
xbp1_1.2	48.4	TRUE	inc

Figure 122: Table of the 40th cluster content

Cluster 50 - 21 transcripts (~ 25% < 5.55 μg/L)

Driver GO terms : COPII-coated vesicle budding

KEGG pathways : Protein processing in endoplasmic reticulum

Wikipathways :

Figure 123: DR curves for the 41st cluster

Figure 124: BMDplot for the 41st cluster

id	BMD.zSD	TF	trend
atf6	30.3	TRUE	dec
dnajb11	2.9	FALSE	dec
dnajc1	33.8	TRUE	inc
dnajc5aa	39.5	FALSE	dec
eif2s1b	34.6	FALSE	inc
ganab	34.4	FALSE	dec
hsp70.1_1.2	52.7	FALSE	inc
hsp70l	68.6	FALSE	inc
hsp90aa1.1	17.7	FALSE	inc
hspa1b	20.5	TRUE	inc
hsph1	4.3	FALSE	inc
march6_1.2	39.1	FALSE	dec
pdia6	5.5	FALSE	dec
rnf185_1.2	28.7	FALSE	inc
RNF5	31.9	FALSE	dec
sar1ab	41.5	FALSE	inc
sar1b	3.8	FALSE	dec
sec23a	5.0	FALSE	dec
sec31b_1.2	37.0	FALSE	dec
selenos	3.2	FALSE	U
xbp1_1.2	48.4	TRUE	inc

Figure 125: Table of the 41st cluster content

Cluster 19 - 20 transcripts (~ 25% < 5.86 μg/L)

Driver GO terms :

KEGG pathways : Ubiquitin mediated proteolysis

Wikipathways :

Figure 126: DR curves for the 42nd cluster

Figure 127: BMDplot for the 42nd cluster

id	BMD.zSD	TF	trend
anapc4_1.2	4.7	FALSE	inc
anapc5	23.6	FALSE	inc
cbl	41.4	TRUE	dec
cdc34b	31.4	FALSE	dec
itcha	47.8	FALSE	dec
itchb	39.3	TRUE	dec
map3k1	5.2	FALSE	dec
trip12_1.2	27.9	FALSE	dec
uba1_1.1	45.7	FALSE	dec
uba1_1.2	45.5	FALSE	dec
uba7	1.8	FALSE	U
ube2a_1.2	4.9	FALSE	inc
ube2al	38.9	FALSE	inc
ube2d2_1.3	7.3	FALSE	bell
ube2d4	30.6	FALSE	dec
ube2ka	37.7	FALSE	inc
ube2l3b_1.1	2.4	FALSE	U
UBE2M_1.4	35.4	FALSE	inc
UBE2M_1.5	30.8	FALSE	dec
wdr26b	6.1	FALSE	dec

Figure 128: Table of the 42nd cluster content

Cluster 23 - 13 transcripts (~ 25% < 6.16 μg/L)

Driver GO terms : polyamine metabolic process

KEGG pathways : Arginine and proline metabolism

Wikipathways :

Figure 129: DR curves for the 43rd cluster

Figure 130: BMDplot for the 43rd cluster

id	BMD.zSD	TF	trend
agmat	2.8	FALSE	dec
arg2	24.5	FALSE	inc
azin1b	53.0	FALSE	inc
ckmb	30.6	FALSE	inc
mao	2.4	FALSE	dec
oat_1.2	35.2	FALSE	inc
oaz2a	4.3	FALSE	dec
oaz2b	45.6	FALSE	inc
odc1_1.3	35.8	FALSE	inc
pycr1b	31.6	FALSE	inc
sat1a.2_1.2	37.4	FALSE	inc
sat2b	26.9	FALSE	inc
smox_1.3	6.2	FALSE	inc

Figure 131: Table of the 43rd cluster content

Cluster 2 - 24 transcripts (~ 25% < 6.53 μg/L)

Driver GO terms : ATP synthesis coupled electron transport

KEGG pathways : Oxidative phosphorylation

Wikipathways : Electron transport chain, Oxidative phosphorylation

Figure 132: DR curves for the 44th cluster

Figure 133: BMDplot for the 44th cluster

id	BMD.zSD	TF	trend
atp5f1c	24.5	FALSE	inc
CABZ01102240.1_1.1	4.2	FALSE	inc
cox6b2	35.3	FALSE	inc
mt-atp8	34.3	FALSE	inc
mt-nd1	30.2	FALSE	inc
mt-nd2	5.3	FALSE	inc
mt-nd3	4.3	FALSE	inc
mt-nd4	3.5	FALSE	inc
mt-nd4l	29.3	FALSE	inc
mt-nd5	6.9	FALSE	U
mt-nd6	3.6	FALSE	inc
ndufaf3	31.1	FALSE	inc
ndufaf5	41.4	FALSE	inc
ndufb11	33.8	FALSE	inc
ndufb5	40.9	FALSE	inc
ndufb6	26.8	FALSE	inc
ndufb8	32.8	FALSE	inc
ndufb9	39.6	FALSE	inc
ndufs2	40.9	FALSE	inc
palb2_1.2	1.7	FALSE	inc
pmpcb	24.4	FALSE	inc
ppa1b	29.1	FALSE	inc
sdhc_1.2	29.1	FALSE	inc
ucp2	53.2	FALSE	inc

Figure 134: Table of the 44th cluster content

Cluster 1 - 137 transcripts (~ 25% < 6.61 μg/L)

Driver GO terms : embryo development ending in birth or egg hatching, myeloid cell differentiation, ribosome biogenesis, translation

KEGG pathways : Ribosome

Wikipathways : Cytoplasmic ribosomal proteins

Figure 135: DR curves for the 45th cluster

Figure 136: BMDplot for the 45th cluster

id	BMD.zSD	TF	trend
aars1_2.2	14.4	FALSE	inc
ahsa1a_1.3	4.5	FALSE	inc
bcl9_1.2	45.0	TRUE	dec
btf3	27.6	FALSE	inc
btf3l4	25.6	FALSE	inc
chd7_1.3	54.7	TRUE	dec
cnbpa_1.1	47.7	FALSE	inc
cnot1_2.1	39.6	FALSE	dec
ddx6	22.0	FALSE	dec
dnm2a_1.2	2.2	FALSE	dec
dohh	32.6	FALSE	inc
edf1	44.6	TRUE	inc
eef1a1l1_1.2	29.8	FALSE	inc
eef1a1l1_1.3	49.8	FALSE	dec
eif2s1b	34.6	FALSE	inc
eif3ba	40.9	FALSE	inc
eif3d_1.4	30.9	FALSE	inc
eif3ea_1.3	5.4	FALSE	inc
eif3f	35.9	FALSE	inc
eif3g	28.0	FALSE	inc
eif3ha	40.4	FALSE	inc
eif3hb_1.2	44.7	FALSE	inc
eif3i	23.9	FALSE	inc
eif3jb	37.2	FALSE	dec
eif3k	44.3	FALSE	inc
eif3m	25.8	FALSE	inc
eif4e2	4.8	FALSE	inc
eif4ebp2	3.4	FALSE	dec
eif4enif1_1.3	32.6	FALSE	dec
eif5a2_1.2	3.0	FALSE	dec
eif5b_1.2	33.2	FALSE	dec
eri1_2.1	29.4	FALSE	inc
faub_2.1	3.1	FALSE	U
flvcr1	2.7	FALSE	inc
furina_2.1	2.8	FALSE	dec
gspt1	33.8	FALSE	inc
hax1	27.2	FALSE	inc
hdac4_1.2	34.3	TRUE	dec
hmgn7_1.2	35.2	FALSE	inc
insrb	35.5	FALSE	dec
kat6a	42.2	TRUE	dec
kif1b_1.1	5.1	FALSE	dec
mdka_1.1	3.3	FALSE	inc
mdka_1.2	46.7	FALSE	inc
mdka_1.4	32.5	FALSE	inc
meis1b_1.1	4.1	TRUE	inc
mettl17_1.4	39.9	FALSE	inc
mrpl15	52.5	FALSE	inc
mrpl3	39.8	FALSE	inc
mrpl4_1.2	36.5	FALSE	inc
mrpl42	40.8	FALSE	inc
mrpl43	36.3	FALSE	inc
mrpl45_2.2	31.9	FALSE	inc
mrps10	29.9	FALSE	inc
mrps15	30.5	FALSE	inc
mrps16_2.1	39.0	FALSE	inc
mrps18a	27.5	FALSE	inc
mrps18b	26.3	FALSE	inc
mrps18c	40.1	FALSE	inc
mrps22_1.4	41.8	FALSE	inc
mrto4	49.4	FALSE	inc
msi2b_1.6	4.1	FALSE	inc
msi2b_1.8	38.4	FALSE	dec
myhz1.1_2.1	2.8	FALSE	inc
nip7	45.5	FALSE	inc
nop53_1.2	31.6	FALSE	inc
nsa2	33.4	FALSE	inc
ntn1a_1.2	39.4	FALSE	dec
paics_1.1	3.1	FALSE	dec
pbx4_1.2	23.0	TRUE	dec
pin4	37.4	FALSE	inc
pitpnaa	3.1	FALSE	dec
rack1_1.1	39.6	FALSE	inc
rack1_1.2	6.6	FALSE	inc
riox1	33.3	FALSE	inc
riox2	30.4	FALSE	inc
rpl10a_1.1	53.4	FALSE	inc
rpl11	41.9	FALSE	inc
rpl12_2.1	39.4	FALSE	inc
rpl13a	39.3	FALSE	inc
rpl14	6.9	FALSE	inc
rpl15	42.9	FALSE	inc
rpl17_1.1	4.6	FALSE	inc
rpl19	35.5	FALSE	inc
rpl23	43.8	FALSE	inc
rpl27	45.8	FALSE	inc
rpl28_1.2	2.1	FALSE	inc
rpl29	51.0	FALSE	inc
rpl3_1.2	7.8	FALSE	inc
rpl32_2.1	25.0	FALSE	inc
rpl35	8.2	FALSE	inc
rpl36a_1.3	46.0	FALSE	inc
rpl38	6.8	FALSE	inc
rpl39	42.0	FALSE	inc
rpl5a	9.0	FALSE	inc
rpl7	33.3	FALSE	inc
rpl7a_1.1	5.9	FALSE	inc
rpl8_1.2	4.6	FALSE	U
rpl9_1.1	7.0	FALSE	inc
rpl9_1.2	31.1	FALSE	inc
rplp0_1.2	6.2	FALSE	inc
rplp2	6.0	FALSE	inc
rps11	39.4	FALSE	inc
rps13_1.1	3.3	FALSE	dec
rps13_1.2	5.8	FALSE	inc
rps15	5.8	FALSE	inc
rps15a	47.0	FALSE	inc
rps18_1.2	28.2	FALSE	inc
rps2_1.1	42.6	FALSE	inc
rps2_1.2	25.0	FALSE	inc
rps24_1.1	3.4	FALSE	inc
rps26	6.6	FALSE	inc
rps27.1	29.3	FALSE	inc
rps27.2_1.2	32.1	FALSE	inc
rps27l	57.9	FALSE	inc
rps29	4.8	FALSE	inc
rps3a_1.1	42.5	FALSE	inc
rps5	8.7	FALSE	inc
rps6	36.0	FALSE	inc
rps7	7.9	FALSE	inc
rps8a	5.0	FALSE	inc
rps9_2.1	2.6	FALSE	inc
rpsa_1.2	59.0	FALSE	inc
sap130b_1.2	28.7	TRUE	dec
serbp1b	33.0	FALSE	dec
shroom3_1.2	55.4	FALSE	dec
si:ch211-207d6.2	4.3	FALSE	dec
si:dkey-151g10.6	3.5	FALSE	inc
si:dkey-46g23.1_1.1	40.9	FALSE	dec
si:dkey-96n2.1	3.6	FALSE	inc
snu13b	40.3	FALSE	inc
srp54	48.8	FALSE	inc
srpra	3.4	FALSE	dec
tfap2c_1.2	1.6	TRUE	dec
tnrc6c1_1.4	59.3	FALSE	dec
UTP14C	52.0	FALSE	dec
utp6_3.1	39.3	FALSE	inc

Figure 137: Table of the 45th cluster content

Cluster 24 - 28 transcripts (~ 25% < 7.45 μg/L)

Driver GO terms : microtubule-based process

KEGG pathways :

Wikipathways :

Figure 138: DR curves for the 46th cluster

Figure 139: BMDplot for the 46th cluster

id	BMD.zSD	TF	trend
cep192_1.2	40.0	FALSE	inc
cep57	3.2	FALSE	inc
cfap298	19.0	FALSE	inc
ckap5_1.2	8.2	FALSE	inc
cpeb2_1.1	3.2	FALSE	bell
cpeb3	34.9	FALSE	dec
CU929259.1	22.5	FALSE	dec
dynll2b	3.7	FALSE	inc
fyco1a_1.2	3.9	FALSE	dec
gas2l1_1.2	25.8	FALSE	dec
gas2l3	41.1	FALSE	dec
haus4	30.8	FALSE	inc
hnrnpua	45.0	FALSE	dec
kif1b_1.1	5.1	FALSE	dec
kif2c_1.3	39.0	FALSE	inc
kifc1_1.2	26.2	FALSE	inc
kifc3_1.5	45.1	FALSE	dec
map1ab_1.2	39.8	FALSE	dec
map4l_1.4	4.6	FALSE	bell
map7d2a_1.1	58.5	FALSE	dec
nckap5l	33.5	FALSE	dec
plk1	45.8	FALSE	inc
si:ch73-217b7.1_1.2	35.1	FALSE	dec
tacc3_1.2	30.5	FALSE	inc
tppp2_2.1	42.5	FALSE	inc
tubb4b_1.2	2.5	FALSE	dec
zgc:86764_1.2	46.1	FALSE	inc
zgc:92429	35.7	FALSE	inc

Figure 140: Table of the 46th cluster content

Cluster 27 - 6 transcripts (~ 25% < 7.85 μg/L)

Driver GO terms :

KEGG pathways :

Wikipathways :

Figure 141: DR curves for the 47th cluster

Figure 142: BMDplot for the 47th cluster

id	BMD.zSD	TF	trend
bms1_2.1	2.9	FALSE	dec
glmna	34.4	FALSE	inc
ncoa6_1.2	2.5	FALSE	inc
ncoa6_1.3	32.4	FALSE	dec
ngdn	42.8	FALSE	inc
pno1	22.7	FALSE	inc

Figure 143: Table of the 47th cluster content

Cluster 61 - 9 transcripts (~ 25% < 9.13 μg/L)

Driver GO terms :

KEGG pathways : Adherens junction

Wikipathways :

Figure 144: DR curves for the 48th cluster

Figure 145: BMDplot for the 48th cluster

id	BMD.zSD	TF	trend
afdna_1.1	45.2	FALSE	dec
cdh1_1.2	4.4	FALSE	dec
farp2_1.2	9.1	FALSE	U
insrb	35.5	FALSE	dec
pvrl2l	39.2	FALSE	dec
si:ch73-22o12.1	36.6	FALSE	dec
si:dkey-222b8.1_2.1	30.3	TRUE	dec
tcf7l1a_1.2	34.9	TRUE	dec
tcf7l1b_1.1	5.1	TRUE	dec

Figure 146: Table of the 48th cluster content

Cluster 53 - 10 transcripts (~ 25% < 9.6 μg/L)

Driver GO terms :

KEGG pathways : Vascular smooth muscle contraction

Wikipathways :

Figure 147: DR curves for the 49th cluster

Figure 148: BMDplot for the 49th cluster

id	BMD.zSD	TF	trend
adma	38.2	FALSE	inc
gna11b	39.7	FALSE	dec
gnas_1.2	34.9	FALSE	dec
mylkb_1.2	2.9	FALSE	dec
ppp1caa	23.1	FALSE	dec
ppp1cbl	36.0	FALSE	inc
ppp1r12a	31.7	FALSE	dec
ppp1r14aa	63.5	FALSE	inc
proca1	3.7	FALSE	inc
si:ch73-265d7.2	5.1	FALSE	inc

Figure 149: Table of the 49th cluster content

Cluster 35 - 47 transcripts (~ 25% < 11.62 μg/L)

Driver GO terms : ribosome biogenesis, protein glycosylation

KEGG pathways : Ribosome biogenesis in eukaryotes, N-Glycan biosynthesis, Protein processing in endoplasmic reticulum, Various types of N-glycan biosynthesis

Wikipathways :

Figure 150: DR curves for the 50th cluster

Figure 151: BMDplot for the 50th cluster

id	BMD.zSD	TF	trend
alg11_1.2	23.4	FALSE	dec
atf6	30.3	TRUE	dec
crppa	19.0	FALSE	inc
dnajb11	2.9	FALSE	dec
dnajc1	33.8	TRUE	inc
dnajc5aa	39.5	FALSE	dec
eif2s1b	34.6	FALSE	inc
emg1	48.1	FALSE	inc
eri1_2.1	29.4	FALSE	inc
ext1c_1.1	1.5	FALSE	inc
ganab	34.4	FALSE	dec
hsp70.1_1.2	52.7	FALSE	inc
hsp70l	68.6	FALSE	inc
hsp90aa1.1	17.7	FALSE	inc
hspa1b	20.5	TRUE	inc
hsph1	4.3	FALSE	inc
man2a1	3.1	FALSE	dec
march6_1.2	39.1	FALSE	dec
mgat5	35.6	FALSE	dec
mlec	2.9	FALSE	dec
nip7	45.5	FALSE	inc
nmd3	48.1	FALSE	inc
noc4l	43.0	FALSE	inc
nop58	2.6	FALSE	dec
ogt.1_2.1	2.9	FALSE	inc
pdia6	5.5	FALSE	dec
pin4	37.4	FALSE	inc
pomgnt1_1.2	33.9	FALSE	inc
pomgnt1_2.1	36.1	FALSE	inc
pomt2	29.4	FALSE	inc
ran	30.5	TRUE	inc
rnf185_1.2	28.7	FALSE	inc
RNF5	31.9	FALSE	dec
rpn1_1.2	3.3	FALSE	dec
rpn2_1.1	4.0	FALSE	dec
rrp7a	39.9	FALSE	inc
selenos	3.2	FALSE	U
snu13b	40.3	FALSE	inc
srd5a3	25.2	FALSE	inc
st6galnac4	23.1	FALSE	dec
stt3b	3.3	FALSE	dec
trub2	31.9	FALSE	inc
UTP14C	52.0	FALSE	dec
utp6_3.1	39.3	FALSE	inc
xbp1_1.2	48.4	TRUE	inc
xrn1	35.5	FALSE	dec
xrn2_1.2	28.1	TRUE	dec

Figure 152: Table of the 50th cluster content