Report of the workflow results

Author

Ellis Franklin

Published

2024-04-28

1 The results as an interactive table

2 The results as sensitivity plots

Figure 1: Sensitivity plot of clusters summarised by BMD first quartile


Figure 2: Sensitivity plot of clusters summarised by BMD median with the interquartile range as an interval

3 The top 50 most sensitive clusters

Cluster 46 - 5 transcripts (~ 25% < 1.39 μg/L)

Driver GO terms :

KEGG pathways : Sphingolipid metabolism

Wikipathways :

Figure 3: DR curves for the 1st cluster
Figure 4: BMDplot for the 1st cluster
id BMD.zSD TF trend
b4galt6 38.51 FALSE dec
cers5 2.59 FALSE dec
enpp7.1_3.1 0.84 FALSE U
gba2_1.2 1.39 FALSE dec
smpd3 49.35 FALSE dec
Figure 5: Table of the 1st cluster content


Cluster 69 - 3 transcripts (~ 25% < 1.53 μg/L)

Driver GO terms :

KEGG pathways :

Wikipathways :

Figure 6: DR curves for the 2nd cluster
Figure 7: BMDplot for the 2nd cluster
id BMD.zSD TF trend
chia.1 0.3 FALSE U
hexb_1.3 39.7 FALSE dec
st3gal7 2.8 FALSE dec
Figure 8: Table of the 2nd cluster content


Cluster 43 - 9 transcripts (~ 25% < 1.95 μg/L)

Driver GO terms :

KEGG pathways : Retinol metabolism

Wikipathways :

Figure 9: DR curves for the 3rd cluster
Figure 10: BMDplot for the 3rd cluster
id BMD.zSD TF trend
cyp27c1 7.3 FALSE inc
cyp3c1_1.2 42.0 FALSE inc
cyp3c3_2.1 1.2 FALSE U
lrata 37.8 FALSE inc
lratb.2 1.9 FALSE inc
ugt1b1_1.2 3.8 FALSE dec
ugt2a7_2.2 2.5 FALSE dec
ugt2a7_3.1 1.7 FALSE dec
zgc:77938 2.9 FALSE dec
Figure 11: Table of the 3rd cluster content


Cluster 86 - 3 transcripts (~ 25% < 2.34 μg/L)

Driver GO terms :

KEGG pathways :

Wikipathways :

Figure 12: DR curves for the 4th cluster
Figure 13: BMDplot for the 4th cluster
id BMD.zSD TF trend
lims2 4.6 FALSE inc
parvaa 2.1 FALSE dec
parvb_1.3 2.6 FALSE inc
Figure 14: Table of the 4th cluster content


Cluster 10 - 16 transcripts (~ 25% < 2.35 μg/L)

Driver GO terms : sphingolipid metabolic process

KEGG pathways : Sphingolipid metabolism

Wikipathways :

Figure 15: DR curves for the 5th cluster
Figure 16: BMDplot for the 5th cluster
id BMD.zSD TF trend
asah2 1.3 FALSE dec
atg12_1.2 31.1 FALSE inc
atg3 2.2 FALSE U
cers2a_1.2 25.8 FALSE dec
cers3a_1.2 1.7 FALSE dec
cers5 2.6 FALSE dec
kdsr_1.2 2.4 FALSE dec
pi4kaa 42.3 FALSE dec
pik3c3_1.2 3.9 FALSE inc
plpp3 5.3 FALSE dec
rab5ab 1.7 FALSE dec
sgpl1_1.1 2.6 FALSE dec
SPHK1 36.0 FALSE dec
sphk2 3.6 FALSE dec
st6galnac4 23.1 FALSE dec
ugt8_2.1 4.1 FALSE dec
Figure 17: Table of the 5th cluster content


Cluster 68 - 17 transcripts (~ 25% < 2.36 μg/L)

Driver GO terms :

KEGG pathways : Lysosome

Wikipathways :

Figure 18: DR curves for the 6th cluster
Figure 19: BMDplot for the 6th cluster
id BMD.zSD TF trend
ap3s2_1.3 3.4 FALSE inc
ap4s1_1.4 35.2 FALSE inc
cltb 2.8 FALSE dec
cts12 52.4 FALSE dec
ctsh 33.8 FALSE inc
ctss2.2 58.7 FALSE inc
gga3b 42.6 FALSE dec
gnptab_1.2 2.3 FALSE U
gnptg 37.4 FALSE inc
lgmn_1.2 1.5 FALSE U
litaf_1.3 43.3 TRUE inc
mcoln1a 2.8 FALSE dec
nagpa 1.9 FALSE dec
pla2g15 2.4 FALSE dec
ppt1_1.2 45.4 FALSE inc
ppt2_1.3 2.2 FALSE bell
slc17a5 3.5 FALSE dec
Figure 20: Table of the 6th cluster content


Cluster 17 - 28 transcripts (~ 25% < 2.55 μg/L)

Driver GO terms : lipid biosynthetic process

KEGG pathways : Steroid biosynthesis

Wikipathways : Cholesterol biosynthesis

Figure 21: DR curves for the 7th cluster
Figure 22: BMDplot for the 7th cluster
id BMD.zSD TF trend
acsl1b 2.18 FALSE dec
alox12 3.38 FALSE dec
cers5 2.59 FALSE dec
crppa 18.97 FALSE inc
cyp17a1 2.73 FALSE dec
cyp27b1 3.01 FALSE dec
dhcr7 2.41 FALSE dec
ERG28 41.26 FALSE dec
fa2h_1.3 1.67 FALSE dec
fdft1_1.2 1.49 FALSE dec
fitm1l 27.73 FALSE inc
gpam 30.83 FALSE dec
hmgcs1_1.2 2.98 FALSE dec
impad1 2.66 FALSE dec
insig2 36.86 FALSE dec
lss 0.49 FALSE U
nus1 28.81 FALSE dec
PYURF_1.1 7.37 FALSE inc
sc5d 2.28 FALSE dec
scap 37.09 FALSE dec
sccpdha.1 1.98 FALSE dec
scd 23.97 FALSE inc
si:dkey-205h13.1_1.2 3.42 FALSE inc
si:dkey-91i10.3 3.26 FALSE dec
st6galnac4 23.11 FALSE dec
tamm41 34.60 FALSE inc
ugt8_2.1 4.12 FALSE dec
zgc:77375 34.02 FALSE dec
Figure 23: Table of the 7th cluster content


Cluster 73 - 14 transcripts (~ 25% < 2.96 μg/L)

Driver GO terms : fatty acid transport

KEGG pathways : PPAR signaling pathway

Wikipathways : PPAR signaling pathway

Figure 24: DR curves for the 8th cluster
Figure 25: BMDplot for the 8th cluster
id BMD.zSD TF trend
acox3 3.06 FALSE dec
acsl1b 2.18 FALSE dec
CABZ01055347.1 26.93 FALSE dec
cd36 0.38 FALSE U
cpt1aa_1.2 2.96 FALSE dec
cyp8b2 2.21 FALSE dec
fabp3 38.40 FALSE inc
fabp7a_1.1 3.60 FALSE inc
fabp7b 39.95 FALSE inc
proca1 3.66 FALSE inc
rbp7b_1.2 17.67 FALSE inc
scd 23.97 FALSE inc
si:dkey-91i10.3 3.26 FALSE dec
slc27a4_1.1 2.98 FALSE dec
Figure 26: Table of the 8th cluster content


Cluster 76 - 36 transcripts (~ 25% < 2.98 μg/L)

Driver GO terms : intracellular protein transport

KEGG pathways :

Wikipathways :

Figure 27: DR curves for the 9th cluster
Figure 28: BMDplot for the 9th cluster
id BMD.zSD TF trend
ap1b1_1.1 35.91 FALSE dec
ap1g1 43.08 FALSE dec
ap1s2_1.2 49.21 FALSE inc
ap2m1a_1.2 32.77 FALSE inc
ap2m1a_1.4 2.24 FALSE dec
ap3s2_1.3 3.43 FALSE inc
ap4s1_1.4 35.23 FALSE inc
appbp2 40.08 FALSE dec
clta_1.3 2.25 FALSE dec
cltb 2.76 FALSE dec
copz1 32.50 FALSE inc
efhc1 4.30 FALSE bell
erbin_1.4 31.50 TRUE dec
gga1_2.1 51.01 FALSE dec
gga3b 42.59 FALSE dec
kpna1 2.82 FALSE bell
kpna3 2.48 FALSE dec
kpna6_1.2 36.86 FALSE dec
LO017722.1 28.03 FALSE dec
mon1a 2.03 FALSE dec
napbb_1.2 36.34 FALSE dec
pex10 0.63 FALSE U
pex14_1.2 3.77 TRUE dec
rab11a 4.30 FALSE dec
rab1ba 22.42 FALSE dec
rab5aa 36.94 FALSE dec
ranbp3b 29.35 FALSE dec
RIC1 31.81 FALSE dec
selenos 3.23 FALSE U
snx27a 26.89 FALSE dec
strada 2.09 FALSE inc
STRADB 48.37 FALSE dec
tgfbrap1 23.45 FALSE dec
tmed2_1.2 1.76 FALSE dec
vps37c 32.36 FALSE dec
zgc:77650_1.1 3.04 FALSE inc
Figure 29: Table of the 9th cluster content


Cluster 42 - 4 transcripts (~ 25% < 3.01 μg/L)

Driver GO terms :

KEGG pathways :

Wikipathways :

Figure 30: DR curves for the 10th cluster
Figure 31: BMDplot for the 10th cluster
id BMD.zSD TF trend
cbfa2t3_1.2 2.5 FALSE bell
ldb1b_1.2 31.6 TRUE dec
lmo1_1.1 3.2 TRUE inc
tcf3a_1.2 35.7 TRUE dec
Figure 32: Table of the 10th cluster content


Cluster 30 - 27 transcripts (~ 25% < 3.07 μg/L)

Driver GO terms : myofibril assembly, striated muscle contraction

KEGG pathways : Motor proteins

Wikipathways :

Figure 33: DR curves for the 11th cluster
Figure 34: BMDplot for the 11th cluster
id BMD.zSD TF trend
chchd10_1.2 41.09 FALSE inc
cx39.9 27.78 FALSE inc
dctn1a_1.2 35.74 FALSE dec
dctn4_1.3 4.08 FALSE bell
dynll2b 3.69 FALSE inc
erp44 3.03 FALSE dec
kif1b_1.1 5.11 FALSE dec
kifc1_1.2 26.20 FALSE inc
kifc3_1.5 45.08 FALSE dec
myhz1.1_2.1 2.79 FALSE inc
myhz1.2_1.2 1.92 FALSE inc
myhz1.3 4.89 FALSE inc
myo1b_1.3 2.90 FALSE dec
MYO1D 4.14 FALSE dec
prox1a 46.70 TRUE dec
scn4ba 34.66 FALSE dec
smyd1b_1.2 34.90 TRUE inc
tfpi2 3.11 FALSE inc
thrab_1.2 40.74 TRUE dec
tnnc2 6.22 FALSE inc
tnni2a.4_1.2 24.82 FALSE inc
tnni4b.2 29.69 FALSE inc
tnnt1_1.2 0.16 FALSE bell
tnnt1_1.3 51.02 FALSE inc
tnnt3b_1.4 3.91 FALSE inc
tnnt3b_1.5 1.94 FALSE inc
tubb4b_1.2 2.47 FALSE dec
Figure 35: Table of the 11th cluster content


Cluster 69 - 3 transcripts (~ 25% < 1.53 μg/L)

Driver GO terms :

KEGG pathways :

Wikipathways :

Figure 36: DR curves for the 12th cluster
Figure 37: BMDplot for the 12th cluster
id BMD.zSD TF trend
chia.1 0.3 FALSE U
hexb_1.3 39.7 FALSE dec
st3gal7 2.8 FALSE dec
Figure 38: Table of the 12th cluster content


Cluster 100 - 9 transcripts (~ 25% < 3.19 μg/L)

Driver GO terms : tRNA processing

KEGG pathways :

Wikipathways :

Figure 39: DR curves for the 13th cluster
Figure 40: BMDplot for the 13th cluster
id BMD.zSD TF trend
gtpbp3_1.3 3.2 FALSE inc
mto1 52.4 FALSE inc
pop4_2.1 35.8 FALSE inc
rtcb_1.2 3.9 FALSE U
thumpd3_2.1 31.2 FALSE inc
trmt1l_1.2 49.5 FALSE inc
trmt6 1.9 FALSE U
trmu 2.3 FALSE U
tsen2 3.3 FALSE inc
Figure 41: Table of the 13th cluster content


Cluster 58 - 3 transcripts (~ 25% < 3.31 μg/L)

Driver GO terms :

KEGG pathways :

Wikipathways :

Figure 42: DR curves for the 14th cluster
Figure 43: BMDplot for the 14th cluster
id BMD.zSD TF trend
cdc73_1.2 3.9 TRUE U
ssrp1b_1.3 2.7 TRUE inc
supt6h 51.6 TRUE dec
Figure 44: Table of the 14th cluster content


Cluster 48 - 44 transcripts (~ 25% < 3.34 μg/L)

Driver GO terms :

KEGG pathways : Regulation of actin cytoskeleton, Salmonella infection, Tight junction

Wikipathways :

Figure 45: DR curves for the 15th cluster
Figure 46: BMDplot for the 15th cluster
id BMD.zSD TF trend
abi1b_1.2 49.3 FALSE dec
acbd3 27.1 FALSE dec
ACBD3 2.6 FALSE dec
actb2_1.2 3.8 TRUE dec
actr2a 4.6 FALSE dec
actr2b 5.2 FALSE dec
akt3a_1.2 37.9 FALSE dec
arf2a_1.1 2.6 FALSE U
arf2a_1.2 3.0 FALSE dec
arhgap35a 34.2 TRUE dec
cldn11a 46.6 FALSE inc
cldna 2.9 FALSE dec
cldnk 3.4 FALSE inc
dctn1a_1.2 35.7 FALSE dec
dctn4_1.3 4.1 FALSE bell
dnm2a_1.2 2.2 FALSE dec
dynll2b 3.7 FALSE inc
enah_1.2 5.5 FALSE U
enah_1.3 38.4 FALSE inc
ezra 3.1 FALSE dec
ezrb_1.3 4.2 TRUE dec
fgd1_1.4 39.3 FALSE dec
fyco1a_1.2 3.9 FALSE dec
hdr_1.2 2.0 FALSE dec
hsp90aa1.1 17.7 FALSE inc
itgb8 49.1 FALSE dec
jam2a_1.3 38.9 FALSE inc
kpna1 2.8 FALSE bell
kpna3 2.5 FALSE dec
map3k1 5.2 FALSE dec
mapk14b_1.3 57.9 FALSE dec
myh9b_1.2 3.6 FALSE dec
mylkb_1.2 2.9 FALSE dec
pak4 4.1 FALSE dec
pak6a 43.7 FALSE dec
pard6b 7.5 FALSE dec
ppp2r2bb_1.3 4.7 FALSE bell
ppp2r2d 21.2 FALSE dec
rab5aa 36.9 FALSE dec
tcf7l1a_1.2 34.9 TRUE dec
tcf7l1b_1.1 5.1 TRUE dec
tjap1 32.4 FALSE dec
tubb4b_1.2 2.5 FALSE dec
zgc:112437 41.2 FALSE inc
Figure 47: Table of the 15th cluster content


Cluster 59 - 13 transcripts (~ 25% < 3.34 μg/L)

Driver GO terms : nucleotide biosynthetic process

KEGG pathways :

Wikipathways :

Figure 48: DR curves for the 16th cluster
Figure 49: BMDplot for the 16th cluster
id BMD.zSD TF trend
acsl1b 2.2 FALSE dec
adka_1.2 3.3 FALSE dec
ak1 6.3 FALSE inc
ampd3b 3.0 FALSE dec
atp5f1c 24.5 FALSE inc
dut 32.5 FALSE inc
impdh1b_1.2 33.6 FALSE dec
mt-atp8 34.3 FALSE inc
nme6 38.5 FALSE inc
paics_1.1 3.1 FALSE dec
prtfdc1_1.2 36.6 FALSE inc
si:ch73-265d7.2 5.1 FALSE inc
umps 54.2 FALSE inc
Figure 50: Table of the 16th cluster content


Cluster 16 - 41 transcripts (~ 25% < 3.41 μg/L)

Driver GO terms : organic acid metabolic process

KEGG pathways : 2-Oxocarboxylic acid metabolism, Biosynthesis of amino acids, Carbon metabolism, Citrate cycle (TCA cycle), Glyoxylate and dicarboxylate metabolism

Wikipathways : TCA cycle

Figure 51: DR curves for the 17th cluster
Figure 52: BMDplot for the 17th cluster
id BMD.zSD TF trend
abcd1_1.2 4.7 FALSE dec
aco1 3.4 FALSE dec
acox3 3.1 FALSE dec
acsl1b 2.2 FALSE dec
acss2l 27.5 FALSE inc
adi1 28.8 FALSE inc
aldh1l1_2.1 2.9 FALSE dec
alox12 3.4 FALSE dec
asdurf_1.2 40.5 FALSE inc
aspg_1.3 14.0 FALSE inc
azin1b 53.0 FALSE inc
cad_1.2 27.1 FALSE inc
cpt1aa_1.2 3.0 FALSE dec
cs 4.6 FALSE dec
cyp2ad3 33.4 FALSE inc
cyp2ad6 29.1 FALSE inc
eno1a_1.2 5.3 FALSE inc
fa2h_1.3 1.7 FALSE dec
glulb_1.1 36.3 FALSE inc
glulb_1.2 30.2 FALSE inc
gpam 30.8 FALSE dec
hacl1_1.2 3.5 FALSE U
hkdc1_2.1 3.1 FALSE dec
HPDL 28.3 FALSE inc
idh2 3.7 FALSE inc
insrb 35.5 FALSE dec
mdh1aa_1.2 2.8 FALSE inc
oat_1.2 35.2 FALSE inc
pa2g4b_1.1 59.1 FALSE inc
pak1ip1 23.7 FALSE inc
pdk1 32.3 FALSE dec
pgk1 36.4 FALSE inc
phgdh 17.9 FALSE inc
psat1 9.3 FALSE inc
pus7_1.3 3.0 FALSE U
pycr1b 31.6 FALSE inc
rsl24d1 33.2 FALSE inc
scd 24.0 FALSE inc
sdsl 1.2 FALSE dec
wdr18 27.9 FALSE inc
znf593 31.1 TRUE inc
Figure 53: Table of the 17th cluster content


Cluster 67 - 10 transcripts (~ 25% < 3.46 μg/L)

Driver GO terms : amino acid transport

KEGG pathways :

Wikipathways :

Figure 54: DR curves for the 18th cluster
Figure 55: BMDplot for the 18th cluster
id BMD.zSD TF trend
slc1a4_1.2 3.6 FALSE inc
slc1a8b_1.1 3.4 FALSE inc
slc25a55b 39.0 FALSE dec
slc3a2b 3.4 FALSE inc
slc6a6a 41.3 FALSE dec
slc7a1a_2.2 3.5 FALSE dec
slc7a2_2.1 2.4 FALSE U
slc7a5_2.1 37.8 FALSE dec
slc7a8a 34.3 FALSE dec
zgc:158423_2.1 37.7 FALSE inc
Figure 56: Table of the 18th cluster content


Cluster 39 - 40 transcripts (~ 25% < 3.47 μg/L)

Driver GO terms : carbohydrate metabolic process

KEGG pathways : N-Glycan biosynthesis, Protein processing in endoplasmic reticulum

Wikipathways :

Figure 57: DR curves for the 19th cluster
Figure 58: BMDplot for the 19th cluster
id BMD.zSD TF trend
agla_1.1 3.0 FALSE dec
atf6 30.3 TRUE dec
CABZ01079192.1 1.7 FALSE dec
CR759923.1_1.4 2.2 FALSE inc
CR774178.2 5.1 FALSE dec
dnajb11 2.9 FALSE dec
dnajc1 33.8 TRUE inc
dnajc5aa 39.5 FALSE dec
eif2s1b 34.6 FALSE inc
eno1a_1.2 5.3 FALSE inc
ganab 34.4 FALSE dec
GANAB_1.2 2.6 FALSE dec
gcgra_2.1 3.5 FALSE dec
hexa_1.1 30.8 FALSE dec
hkdc1_2.1 3.1 FALSE dec
hsp70.1_1.2 52.7 FALSE inc
hsp70l 68.6 FALSE inc
hsp90aa1.1 17.7 FALSE inc
hspa1b 20.5 TRUE inc
hsph1 4.3 FALSE inc
insrb 35.5 FALSE dec
kctd10 4.7 FALSE U
lancl1 1.9 FALSE inc
man1a1 36.4 FALSE dec
man1b1b 36.7 FALSE dec
MAN1C1_1.2 29.0 FALSE dec
man2a1 3.1 FALSE dec
march6_1.2 39.1 FALSE dec
mgat5 35.6 FALSE dec
myorg 3.3 FALSE dec
pdia6 5.5 FALSE dec
pdk1 32.3 FALSE dec
pgk1 36.4 FALSE inc
rnf185_1.2 28.7 FALSE inc
RNF5 31.9 FALSE dec
selenos 3.2 FALSE U
spata20 27.8 FALSE inc
srd5a3 25.2 FALSE inc
st6galnac4 23.1 FALSE dec
xbp1_1.2 48.4 TRUE inc
Figure 59: Table of the 19th cluster content


Cluster 89 - 6 transcripts (~ 25% < 3.71 μg/L)

Driver GO terms :

KEGG pathways : Arachidonic acid metabolism

Wikipathways :

Figure 60: DR curves for the 20th cluster
Figure 61: BMDplot for the 20th cluster
id BMD.zSD TF trend
alox12 3.4 FALSE dec
gpx4b 22.6 FALSE inc
proca1 3.7 FALSE inc
prxl2b_1.2 3.9 FALSE dec
ptgdsb.2 41.7 FALSE inc
ptges3b 46.2 FALSE inc
Figure 62: Table of the 20th cluster content


Cluster 8 - 56 transcripts (~ 25% < 3.74 μg/L)

Driver GO terms : generation of precursor metabolites and energy, muscle system process

KEGG pathways : Cardiac muscle contraction, Oxidative phosphorylation, Vascular smooth muscle contraction

Wikipathways : Electron transport chain, Oxidative phosphorylation

Figure 63: DR curves for the 21st cluster
Figure 64: BMDplot for the 21st cluster
id BMD.zSD TF trend
adma 38.2 FALSE inc
agla_1.1 3.0 FALSE dec
atp1a3a 58.6 FALSE dec
atp2a1_1.1 43.0 FALSE inc
atp2a2b 3.3 FALSE dec
atp2a3_1.3 2.8 FALSE dec
atp5f1c 24.5 FALSE inc
BX936363.1 33.6 FALSE dec
cacng1a 30.6 FALSE inc
cald1a 4.6 FALSE dec
cald1b_1.2 23.7 FALSE dec
coa6 4.6 FALSE inc
cox11_1.2 32.8 FALSE inc
cox7a2a_1.2 38.4 FALSE inc
cx39.9 27.8 FALSE inc
eno1a_1.2 5.3 FALSE inc
erp44 3.0 FALSE dec
foxo3b 39.2 TRUE dec
gna11b 39.7 FALSE dec
gnas_1.2 34.9 FALSE dec
hkdc1_2.1 3.1 FALSE dec
htr1d 2.7 FALSE inc
insrb 35.5 FALSE dec
lamtor3 33.8 FALSE inc
lsp1a 4.3 FALSE dec
mapk3 24.9 FALSE dec
mt-atp6 3.5 FALSE inc
mt-atp8 34.3 FALSE inc
mt-co1 3.8 FALSE inc
mt-co2 5.5 FALSE inc
mt-co3 3.6 FALSE inc
mt-cyb 3.7 FALSE inc
mt-nd2 5.3 FALSE inc
myhz1.1_2.1 2.8 FALSE inc
myhz1.3 4.9 FALSE inc
mylkb_1.2 2.9 FALSE dec
mylpfa_1.2 4.6 FALSE inc
oxct1a_1.2 3.2 FALSE inc
pgk1 36.4 FALSE inc
ppa1b 29.1 FALSE inc
proca1 3.7 FALSE inc
rock2a_1.2 3.6 FALSE U
scn4ba 34.7 FALSE dec
sco1_1.1 44.6 FALSE inc
sdhb 40.8 FALSE inc
sdhc_1.2 29.1 FALSE inc
si:ch211-139a5.9_1.1 29.7 FALSE inc
si:ch73-265d7.2 5.1 FALSE inc
slc25a55b 39.0 FALSE dec
slc8a2b 47.0 FALSE dec
soul4 49.9 FALSE dec
stmn1a_1.2 33.9 FALSE inc
stmn1a_1.3 21.2 FALSE inc
surf1 35.7 FALSE inc
trdn_1.4 57.1 FALSE dec
ucp2 53.2 FALSE inc
Figure 65: Table of the 21st cluster content


Cluster 14 - 25 transcripts (~ 25% < 3.75 μg/L)

Driver GO terms : protein folding

KEGG pathways :

Wikipathways :

Figure 66: DR curves for the 22nd cluster
Figure 67: BMDplot for the 22nd cluster
id BMD.zSD TF trend
ahsa1a_1.3 4.5 FALSE inc
CABZ01080568.1 17.8 FALSE inc
cct2_1.1 6.8 FALSE inc
cct3 36.1 FALSE inc
cct4 36.4 FALSE inc
cct5 38.4 FALSE inc
cct6a_1.3 37.5 FALSE inc
cct7 49.6 FALSE inc
cct8_1.2 3.1 FALSE inc
cryaa_2.1 30.1 FALSE dec
dnajb11 2.9 FALSE dec
dnajc18 3.8 FALSE inc
dnajc5aa 39.5 FALSE dec
erp44 3.0 FALSE dec
hsp70.1_1.2 52.7 FALSE inc
hsp90aa1.1 17.7 FALSE inc
hspa8_2.1 51.2 FALSE inc
p4hb_1.1 2.2 FALSE dec
pfdn5_2.1 40.9 FALSE inc
ppiaa 27.2 FALSE inc
ppid_1.2 25.1 TRUE inc
si:ch211-131k2.3 18.5 FALSE inc
st13 2.8 FALSE dec
tor1_1.2 2.5 FALSE dec
wdr83os_1.1 25.3 FALSE inc
Figure 68: Table of the 22nd cluster content


Cluster 90 - 21 transcripts (~ 25% < 3.75 μg/L)

Driver GO terms : protein folding

KEGG pathways :

Wikipathways :

Figure 69: DR curves for the 23rd cluster
Figure 70: BMDplot for the 23rd cluster
id BMD.zSD TF trend
ahsa1a_1.3 4.5 FALSE inc
CABZ01080568.1 17.8 FALSE inc
cryaa_2.1 30.1 FALSE dec
dnajb11 2.9 FALSE dec
dnajc18 3.8 FALSE inc
dnajc5aa 39.5 FALSE dec
erp44 3.0 FALSE dec
hsp70.1_1.2 52.7 FALSE inc
hsp90aa1.1 17.7 FALSE inc
hspa8_2.1 51.2 FALSE inc
p4hb_1.1 2.2 FALSE dec
pfdn2 32.1 FALSE inc
pfdn4 41.3 FALSE inc
pfdn5_2.1 40.9 FALSE inc
pfdn5_3.1 28.0 TRUE inc
ppiaa 27.2 FALSE inc
ppid_1.2 25.1 TRUE inc
si:ch211-131k2.3 18.5 FALSE inc
st13 2.8 FALSE dec
tor1_1.2 2.5 FALSE dec
wdr83os_1.1 25.3 FALSE inc
Figure 71: Table of the 23rd cluster content


Cluster 44 - 38 transcripts (~ 25% < 3.78 μg/L)

Driver GO terms : canonical NF-kappaB signal transduction

KEGG pathways : Apoptosis, C-type lectin receptor signaling pathway, MAPK signaling pathway

Wikipathways :

Figure 72: DR curves for the 24th cluster
Figure 73: BMDplot for the 24th cluster
id BMD.zSD TF trend
akt3a_1.2 37.91 FALSE dec
apaf1_1.2 0.42 FALSE U
arf2b_1.2 3.69 FALSE dec
cacng1a 30.61 FALSE inc
cts12 52.43 FALSE dec
ctsh 33.75 FALSE inc
ctss2.2 58.70 FALSE inc
cylda_1.2 2.29 FALSE inc
eif2s1b 34.59 FALSE inc
hdr_1.2 2.03 FALSE dec
hsp70.1_1.2 52.68 FALSE inc
hsp70l 68.64 FALSE inc
hspa1b 20.47 TRUE inc
ikbkg_1.1 2.06 TRUE dec
ikbkg_1.2 2.42 TRUE bell
insrb 35.55 FALSE dec
irf2a_1.2 3.10 TRUE inc
irf7_1.2 23.10 TRUE inc
jund 42.72 TRUE dec
ksr1b_1.4 37.30 FALSE inc
lmnb2 20.38 FALSE dec
map3k1 5.24 FALSE dec
map3k14a 35.23 FALSE inc
map4k6 0.79 FALSE bell
mapk14b_1.3 57.92 FALSE dec
mcl1a 24.25 FALSE inc
mef2cb_1.5 41.30 TRUE dec
mtdha_1.2 1.63 FALSE dec
n4bp1 31.11 FALSE dec
plcg2_1.2 4.02 FALSE dec
ppm1ba 32.96 FALSE dec
ppm1bb 28.92 FALSE dec
ptpn13_1.5 0.84 FALSE dec
rps6ka2 4.53 FALSE bell
s100b 27.44 FALSE inc
scaf11_1.1 37.16 FALSE dec
taok1a_1.2 39.92 FALSE dec
taok2b 39.79 FALSE dec
Figure 74: Table of the 24th cluster content


Cluster 63 - 31 transcripts (~ 25% < 3.78 μg/L)

Driver GO terms : glucan metabolic process

KEGG pathways : Calcium signaling pathway, Insulin signaling pathway

Wikipathways :

Figure 75: DR curves for the 25th cluster
Figure 76: BMDplot for the 25th cluster
id BMD.zSD TF trend
agla_1.1 3.0 FALSE dec
akt3a_1.2 37.9 FALSE dec
atp2a1_1.1 43.0 FALSE inc
atp2a2b 3.3 FALSE dec
atp2a3_1.3 2.8 FALSE dec
atp2b1a 40.6 FALSE dec
camk1b 5.7 FALSE dec
cbl 41.4 TRUE dec
eif4e2 4.8 FALSE inc
gna11b 39.7 FALSE dec
gnas_1.2 34.9 FALSE dec
grin1b_1.1 1.8 FALSE inc
insrb 35.5 FALSE dec
irs1 27.5 FALSE dec
mcoln1a 2.8 FALSE dec
MCOLN3_1.3 2.7 FALSE dec
mcu 4.7 FALSE dec
mylkb_1.2 2.9 FALSE dec
pde3b 33.0 FALSE dec
phkb_1.4 4.6 FALSE inc
phkg1b_1.2 42.1 FALSE inc
phkg2 4.6 FALSE U
plcg1_1.1 34.3 FALSE dec
plcg1_1.2 39.7 FALSE dec
plcg2_1.2 4.0 FALSE dec
ppargc1a 37.8 TRUE dec
ppp1r3cb_1.2 39.4 FALSE inc
slc8a2b 47.0 FALSE dec
stim1a_1.3 41.2 FALSE dec
trdn_1.4 57.1 FALSE dec
vdac3_1.1 3.5 FALSE inc
Figure 77: Table of the 25th cluster content


Cluster 83 - 16 transcripts (~ 25% < 3.83 μg/L)

Driver GO terms : Notch signaling pathway

KEGG pathways : Notch signaling pathway

Wikipathways :

Figure 78: DR curves for the 26th cluster
Figure 79: BMDplot for the 26th cluster
id BMD.zSD TF trend
chsy1 43.3 FALSE dec
dlb 4.1 FALSE inc
dtx4a 47.1 FALSE dec
egfl6_1.1 39.9 FALSE inc
gmds_1.1 5.8 FALSE dec
gmds_1.3 3.1 FALSE dec
itcha 47.8 FALSE dec
itchb 39.3 TRUE dec
lfng_1.2 24.1 FALSE inc
notch1a_1.2 2.3 TRUE inc
notch1b_1.3 48.6 FALSE dec
plvapb 57.5 FALSE inc
psen2 1.9 FALSE dec
tcima 31.7 FALSE inc
tet3_1.2 43.3 FALSE dec
tet3_1.3 2.3 FALSE inc
Figure 80: Table of the 26th cluster content


Cluster 70 - 35 transcripts (~ 25% < 3.89 μg/L)

Driver GO terms : canonical Wnt signaling pathway

KEGG pathways : mTOR signaling pathway, Wnt signaling pathway

Wikipathways :

Figure 81: DR curves for the 27th cluster
Figure 82: BMDplot for the 27th cluster
id BMD.zSD TF trend
akt3a_1.2 37.9 FALSE dec
bcl9_1.2 45.0 TRUE dec
cacybp 27.0 FALSE inc
csnk1g2a_1.2 30.3 FALSE dec
cylda_1.2 2.3 FALSE inc
daam1a_1.2 51.7 FALSE dec
depdc5_1.1 3.9 FALSE inc
dot1l_1.3 47.2 FALSE dec
eif4e2 4.8 FALSE inc
fzd1 2.6 FALSE U
fzd10 42.4 FALSE inc
grb10a 3.5 FALSE dec
gskip 3.9 FALSE dec
insrb 35.5 FALSE dec
irs1 27.5 FALSE dec
lrp5_1.2 4.4 FALSE dec
mapkap1_1.2 19.0 FALSE dec
ppm1ba 33.0 FALSE dec
ppm1bb 28.9 FALSE dec
rnf146_1.2 16.9 FALSE dec
rps6ka2 4.5 FALSE bell
sgk2b_1.2 2.3 FALSE inc
si:ch211-195b13.1_1.2 5.5 FALSE inc
si:dkey-1c11.1_1.2 1.7 FALSE inc
si:dkey-222b8.1_2.1 30.3 TRUE dec
strada 2.1 FALSE inc
STRADB 48.4 FALSE dec
tcf7l1a_1.2 34.9 TRUE dec
tcf7l1b_1.1 5.1 TRUE dec
tcf7l2_1.10 42.3 TRUE dec
tet3_1.2 43.3 FALSE dec
tet3_1.3 2.3 FALSE inc
tti1 27.0 FALSE inc
vangl2 36.5 FALSE dec
wnt4b_2.1 1.4 FALSE bell
Figure 83: Table of the 27th cluster content


Cluster 41 - 45 transcripts (~ 25% < 3.92 μg/L)

Driver GO terms : mRNA processing

KEGG pathways : mRNA surveillance pathway

Wikipathways : mRNA processing

Figure 84: DR curves for the 28th cluster
Figure 85: BMDplot for the 28th cluster
id BMD.zSD TF trend
celf2_1.2 32.7 FALSE dec
celf2_1.4 27.6 FALSE dec
clk2a_1.1 7.0 FALSE dec
cpsf3 57.2 FALSE inc
cpsf6_1.2 2.1 FALSE dec
cstf2_1.2 3.7 FALSE inc
ern1 60.3 TRUE dec
hnrnpa1b_1.2 2.2 FALSE inc
hnrnpaba_1.3 7.9 FALSE dec
hnrnpk_1.3 59.0 FALSE dec
hnrnpm_1.3 2.0 FALSE bell
hnrnpm_1.4 33.9 FALSE dec
hnrnpua 45.0 FALSE dec
msi2b_1.6 4.1 FALSE inc
msi2b_1.8 38.4 FALSE dec
pabpn1_1.1 4.6 FALSE inc
pabpn1_1.3 28.7 FALSE dec
papolg 2.3 FALSE bell
pcbp4_1.1 2.5 FALSE dec
ppp2r2bb_1.3 4.7 FALSE bell
ppp2r2d 21.2 FALSE dec
ppp2r3c 26.2 FALSE inc
ptbp3 20.6 FALSE dec
puf60a_1.3 3.5 TRUE inc
qkia_1.2 32.5 FALSE dec
rbm15_2.1 35.7 TRUE dec
rbm26_1.2 32.0 FALSE dec
rbm27 33.7 FALSE dec
rbm39a_1.4 1.4 TRUE dec
rbm39a_1.5 3.9 TRUE inc
rbm39b_1.1 5.1 FALSE inc
rbm4.2 1.8 FALSE bell
rbm4.3 24.1 FALSE dec
rbm5_1.2 36.6 FALSE dec
sf1_1.2 41.2 FALSE dec
smndc1_1.1 51.3 FALSE inc
smx5 29.4 FALSE inc
snrnp25 29.2 FALSE inc
snu13b 40.3 FALSE inc
srsf3b_1.1 52.5 FALSE dec
srsf5b_1.1 3.2 FALSE bell
taf15_1.1 1.4 FALSE dec
thoc7 32.7 FALSE inc
tssc4_1.2 4.8 FALSE inc
xrn2_1.2 28.1 TRUE dec
Figure 86: Table of the 28th cluster content


Cluster 13 - 62 transcripts (~ 25% < 3.99 μg/L)

Driver GO terms : translational initiation, RNA splicing

KEGG pathways : Herpes simplex virus 1 infection, Spliceosome

Wikipathways :

Figure 87: DR curves for the 29th cluster
Figure 88: BMDplot for the 29th cluster
id BMD.zSD TF trend
akt3a_1.2 37.91 FALSE dec
apaf1_1.2 0.42 FALSE U
cdc123_1.2 34.85 FALSE inc
clk2a_1.1 6.97 FALSE dec
ddx5_1.1 2.49 TRUE dec
ddx5_1.4 4.00 TRUE inc
eif2b1_1.2 25.74 FALSE inc
eif2b3_1.2 37.46 FALSE inc
eif2b4_1.2 25.39 FALSE inc
eif2b5 39.41 FALSE inc
eif2s1b 34.59 FALSE inc
eif2s2 40.56 FALSE inc
eif2s3_1.3 29.30 FALSE inc
eif4e2 4.77 FALSE inc
eif4ebp2 3.35 FALSE dec
eif4enif1_1.3 32.65 FALSE dec
hmga1a_1.1 3.64 TRUE dec
hmga1a_1.2 2.80 TRUE dec
hmga1a_1.3 4.91 TRUE inc
hnrnpa1b_1.2 2.18 FALSE inc
hnrnpk_1.3 58.96 FALSE dec
hnrnpm_1.3 1.98 FALSE bell
hnrnpm_1.4 33.91 FALSE dec
hnrnpua 45.03 FALSE dec
hsp70.1_1.2 52.68 FALSE inc
hsp70l 68.64 FALSE inc
hspa1b 20.47 TRUE inc
irf7_1.2 23.10 TRUE inc
mbnl1_1.5 53.83 FALSE inc
pcbp4_1.1 2.54 FALSE dec
ppil1 34.72 FALSE inc
prpf18_1.2 45.14 FALSE dec
ptbp3 20.62 FALSE dec
puf60a_1.3 3.49 TRUE inc
qkia_1.2 32.51 FALSE dec
rbfox1_1.1 47.48 TRUE dec
rbfox1_1.5 38.16 TRUE dec
rbfox1l_1.1 35.52 FALSE inc
rbfox1l_2.1 31.90 FALSE inc
rbm15_2.1 35.69 TRUE dec
rbm4.2 1.85 FALSE bell
rbm4.3 24.11 FALSE dec
rbm5_1.2 36.59 FALSE dec
rp9_1.3 3.20 FALSE inc
rtcb_1.2 3.90 FALSE U
sf1_1.2 41.23 FALSE dec
si:dkey-67c22.2_1.2 27.80 FALSE dec
slu7_1.2 3.98 FALSE dec
snrnp25 29.23 FALSE inc
snrnp27 42.56 FALSE inc
snu13b 40.27 FALSE inc
srsf3b_1.1 52.54 FALSE dec
srsf5b_1.1 3.25 FALSE bell
taf15_1.1 1.39 FALSE dec
tapbp.1 35.67 FALSE inc
thoc1 32.02 FALSE inc
thrap3b_1.4 46.33 FALSE dec
thrap3b_1.5 35.74 FALSE dec
tsen2 3.34 FALSE inc
tssc4_1.2 4.85 FALSE inc
wbp11_1.1 33.15 FALSE dec
zgc:55733_1.2 33.64 TRUE inc
Figure 89: Table of the 29th cluster content


Cluster 54 - 16 transcripts (~ 25% < 4.02 μg/L)

Driver GO terms :

KEGG pathways : Tight junction

Wikipathways :

Figure 90: DR curves for the 30th cluster
Figure 91: BMDplot for the 30th cluster
id BMD.zSD TF trend
cldn11a 46.6 FALSE inc
cldna 2.9 FALSE dec
cldnk 3.4 FALSE inc
dlg1l_1.3 32.7 FALSE dec
dlg1l_1.4 4.1 FALSE dec
ezra 3.1 FALSE dec
ezrb_1.3 4.2 TRUE dec
jam2a_1.3 38.9 FALSE inc
llgl2_1.3 3.9 FALSE dec
map3k1 5.2 FALSE dec
pard6b 7.5 FALSE dec
ppp2r2bb_1.3 4.7 FALSE bell
ppp2r2d 21.2 FALSE dec
scrib_1.3 38.3 FALSE dec
tjap1 32.4 FALSE dec
zgc:112437 41.2 FALSE inc
Figure 92: Table of the 30th cluster content


Cluster 87 - 3 transcripts (~ 25% < 4.2 μg/L)

Driver GO terms :

KEGG pathways :

Wikipathways :

Figure 93: DR curves for the 31st cluster
Figure 94: BMDplot for the 31st cluster
id BMD.zSD TF trend
ift52 5.4 FALSE inc
ttc26 3.0 FALSE inc
zgc:158640 32.8 FALSE inc
Figure 95: Table of the 31st cluster content


Cluster 97 - 20 transcripts (~ 25% < 4.25 μg/L)

Driver GO terms :

KEGG pathways : Protein processing in endoplasmic reticulum

Wikipathways :

Figure 96: DR curves for the 32nd cluster
Figure 97: BMDplot for the 32nd cluster
id BMD.zSD TF trend
atf6 30.3 TRUE dec
calr3b 4.1 FALSE dec
canx 4.1 FALSE dec
dnajb11 2.9 FALSE dec
dnajc1 33.8 TRUE inc
dnajc5aa 39.5 FALSE dec
eif2s1b 34.6 FALSE inc
ganab 34.4 FALSE dec
hsp70.1_1.2 52.7 FALSE inc
hsp70l 68.6 FALSE inc
hsp90aa1.1 17.7 FALSE inc
hspa1b 20.5 TRUE inc
hsph1 4.3 FALSE inc
march6_1.2 39.1 FALSE dec
pdia3_1.2 3.0 FALSE dec
pdia6 5.5 FALSE dec
rnf185_1.2 28.7 FALSE inc
RNF5 31.9 FALSE dec
selenos 3.2 FALSE U
xbp1_1.2 48.4 TRUE inc
Figure 98: Table of the 32nd cluster content


Cluster 12 - 70 transcripts (~ 25% < 4.37 μg/L)

Driver GO terms : RNA splicing, via transesterification reactions

KEGG pathways : Adherens junction, Mitophagy - animal, Ribosome biogenesis in eukaryotes, Wnt signaling pathway, Spliceosome

Wikipathways :

Figure 99: DR curves for the 33rd cluster
Figure 100: BMDplot for the 33rd cluster
id BMD.zSD TF trend
acp1_1.1 32.6 FALSE inc
atg9a_1.4 43.4 FALSE inc
bcl9_1.2 45.0 TRUE dec
cacybp 27.0 FALSE inc
cdh1_1.2 4.4 FALSE dec
csnk1g2a_1.2 30.3 FALSE dec
csnk2a2a 4.6 FALSE inc
csnk2a4 1.0 FALSE U
ctnnb1_1.1 32.8 TRUE dec
cylda_1.2 2.3 FALSE inc
daam1a_1.2 51.7 FALSE dec
dot1l_1.3 47.2 FALSE dec
eif2s1b 34.6 FALSE inc
farp2_1.2 9.1 FALSE U
grb10a 3.5 FALSE dec
gsk3ba 22.3 TRUE dec
gskip 3.9 FALSE dec
hnrnpa1b_1.2 2.2 FALSE inc
hnrnpk_1.3 59.0 FALSE dec
hnrnpm_1.3 2.0 FALSE bell
hnrnpm_1.4 33.9 FALSE dec
hnrnpua 45.0 FALSE dec
hsp70.1_1.2 52.7 FALSE inc
hsp70l 68.6 FALSE inc
hspa1b 20.5 TRUE inc
insrb 35.5 FALSE dec
LSM2_1.4 3.2 FALSE dec
lsm5_1.2 4.4 FALSE inc
mon1a 2.0 FALSE dec
nmd3 48.1 FALSE inc
pcbp4_1.1 2.5 FALSE dec
ppm1ba 33.0 FALSE dec
ppm1bb 28.9 FALSE dec
puf60a_1.3 3.5 TRUE inc
rab5aa 36.9 FALSE dec
ran 30.5 TRUE inc
rbm15_2.1 35.7 TRUE dec
rbm4.2 1.8 FALSE bell
rbm4.3 24.1 FALSE dec
rbm5_1.2 36.6 FALSE dec
rnf146_1.2 16.9 FALSE dec
rp9_1.3 3.2 FALSE inc
sf1_1.2 41.2 FALSE dec
sf3b6 32.7 FALSE inc
si:dkey-1c11.1_1.2 1.7 FALSE inc
si:dkey-222b8.1_2.1 30.3 TRUE dec
snrnp25 29.2 FALSE inc
snrnp27 42.6 FALSE inc
snrpd2 57.0 FALSE inc
snrpg 40.8 FALSE inc
snu13b 40.3 FALSE inc
srsf3b_1.1 52.5 FALSE dec
srsf5b_1.1 3.2 FALSE bell
taf15_1.1 1.4 FALSE dec
tbl1xr1b 4.7 FALSE dec
tcf7l1a_1.2 34.9 TRUE dec
tcf7l1b_1.1 5.1 TRUE dec
tcf7l2_1.10 42.3 TRUE dec
tet3_1.2 43.3 FALSE dec
tet3_1.3 2.3 FALSE inc
thoc1 32.0 FALSE inc
usp8 31.4 FALSE dec
UTP14C 52.0 FALSE dec
vangl2 36.5 FALSE dec
wbp11_1.1 33.1 FALSE dec
wnt4b_2.1 1.4 FALSE bell
xrn1 35.5 FALSE dec
xrn2_1.2 28.1 TRUE dec
zgc:55733_1.2 33.6 TRUE inc
zgc:86598_1.2 27.0 TRUE inc
Figure 101: Table of the 33rd cluster content


Cluster 75 - 10 transcripts (~ 25% < 4.67 μg/L)

Driver GO terms : phospholipid biosynthetic process

KEGG pathways :

Wikipathways :

Figure 102: DR curves for the 34th cluster
Figure 103: BMDplot for the 34th cluster
id BMD.zSD TF trend
fitm1l 27.7 FALSE inc
gpam 30.8 FALSE dec
impad1 2.7 FALSE dec
pisd_2.1 57.1 FALSE dec
ptdss2_1.2 22.7 FALSE dec
PYURF_1.1 7.4 FALSE inc
selenoi 3.8 FALSE dec
si:dkey-205h13.1_1.2 3.4 FALSE inc
tamm41 34.6 FALSE inc
zgc:77375 34.0 FALSE dec
Figure 104: Table of the 34th cluster content


Cluster 9 - 19 transcripts (~ 25% < 4.71 μg/L)

Driver GO terms : transcription by RNA polymerase I, transcription by RNA polymerase III, translational initiation

KEGG pathways : Cytosolic DNA-sensing pathway, RNA polymerase

Wikipathways :

Figure 105: DR curves for the 35th cluster
Figure 106: BMDplot for the 35th cluster
id BMD.zSD TF trend
eif2s1b 34.6 FALSE inc
eif4a2_1.2 4.2 FALSE inc
eif4ba_1.4 41.6 FALSE dec
eif4bb_1.3 4.0 FALSE dec
eif4e2 4.8 FALSE inc
eif4ea_1.1 45.9 FALSE dec
eif4ebp2 3.4 FALSE dec
eif4enif1_1.3 32.6 FALSE dec
eif4g1a_1.3 4.6 FALSE U
irf7_1.2 23.1 TRUE inc
polr1c_1.2 40.8 FALSE inc
polr2c_2.1 30.7 FALSE inc
polr2eb 52.3 FALSE inc
polr2f_1.1 3.7 FALSE dec
polr2h 29.8 FALSE inc
polr2l 41.7 FALSE inc
polr3k 26.9 FALSE inc
rrn3_1.2 37.6 TRUE inc
snapc1b 49.1 FALSE inc
Figure 107: Table of the 35th cluster content


Cluster 80 - 5 transcripts (~ 25% < 4.75 μg/L)

Driver GO terms : iron-sulfur cluster assembly

KEGG pathways :

Wikipathways :

Figure 108: DR curves for the 36th cluster
Figure 109: BMDplot for the 36th cluster
id BMD.zSD TF trend
ciao1 3.9 FALSE U
isca1 25.8 FALSE inc
isca2_1.2 4.8 FALSE inc
ISCU 37.5 FALSE inc
zgc:110319_1.2 37.9 FALSE inc
Figure 110: Table of the 36th cluster content


Cluster 33 - 13 transcripts (~ 25% < 4.81 μg/L)

Driver GO terms :

KEGG pathways : ATP-dependent chromatin remodeling

Wikipathways :

Figure 111: DR curves for the 37th cluster
Figure 112: BMDplot for the 37th cluster
id BMD.zSD TF trend
actr8 44.5 TRUE inc
brd8_1.3 6.9 FALSE dec
brd8_1.4 4.2 FALSE inc
chaf1a_2.2 4.8 FALSE dec
chd3_2.2 30.4 TRUE dec
chrac1_1.2 25.0 TRUE inc
ep400_1.2 3.4 TRUE inc
gatad2b 24.9 TRUE dec
h2ax 28.1 FALSE inc
lin52_1.2 44.3 FALSE inc
rbbp4 36.7 TRUE inc
smarcb1b_1.3 2.9 FALSE inc
yeats4 48.8 TRUE inc
Figure 113: Table of the 37th cluster content


Cluster 94 - 3 transcripts (~ 25% < 5.06 μg/L)

Driver GO terms : microtubule nucleation

KEGG pathways :

Wikipathways :

Figure 114: DR curves for the 38th cluster
Figure 115: BMDplot for the 38th cluster
id BMD.zSD TF trend
tubgcp2 35.0 FALSE inc
tubgcp4 3.4 FALSE inc
tubgcp5 6.7 FALSE inc
Figure 116: Table of the 38th cluster content


Cluster 5 - 44 transcripts (~ 25% < 5.22 μg/L)

Driver GO terms : protein catabolic process

KEGG pathways : Proteasome

Wikipathways :

Figure 117: DR curves for the 39th cluster
Figure 118: BMDplot for the 39th cluster
id BMD.zSD TF trend
anapc4_1.2 4.7 FALSE inc
appbp2 40.1 FALSE dec
arih2_1.1 2.7 FALSE dec
azin1b 53.0 FALSE inc
CR788324.2 33.2 FALSE dec
cylda_1.2 2.3 FALSE inc
desi1a 5.3 FALSE inc
fbxo33 37.8 FALSE dec
hectd3_1.2 2.7 FALSE dec
itcha 47.8 FALSE dec
itchb 39.3 TRUE dec
kctd10 4.7 FALSE U
kctd5a 25.2 FALSE dec
lgmn_1.2 1.5 FALSE U
pomp 37.3 FALSE inc
ppt1_1.2 45.4 FALSE inc
psma3 36.2 FALSE inc
psma4 39.1 FALSE inc
psma5_1.1 33.1 FALSE inc
psma6b_1.2 45.4 FALSE inc
psmb4 47.0 FALSE inc
psmc1a_2.2 42.8 FALSE inc
psmc4_1.2 38.8 FALSE inc
psmd12 51.7 FALSE inc
psmd13 39.2 FALSE inc
psmd14 42.2 FALSE inc
psmd2 5.1 FALSE dec
psmd4a_1.2 47.9 FALSE inc
psme3_1.2 47.1 FALSE inc
psme4b_2.2 1.2 FALSE bell
rnf146_1.2 16.9 FALSE dec
uba7 1.8 FALSE U
ube2a_1.2 4.9 FALSE inc
ube2al 38.9 FALSE inc
usp1_1.2 23.8 FALSE inc
usp14 36.2 FALSE inc
usp24_1.2 35.4 FALSE dec
usp2a_1.4 38.0 FALSE dec
usp2a_1.5 3.8 FALSE inc
usp32 34.3 FALSE dec
usp4 45.4 FALSE dec
usp48_1.2 37.7 FALSE inc
usp8 31.4 FALSE dec
vps37c 32.4 FALSE dec
Figure 119: Table of the 39th cluster content


Cluster 31 - 25 transcripts (~ 25% < 5.53 μg/L)

Driver GO terms :

KEGG pathways : Protein export, Protein processing in endoplasmic reticulum

Wikipathways :

Figure 120: DR curves for the 40th cluster
Figure 121: BMDplot for the 40th cluster
id BMD.zSD TF trend
atf6 30.3 TRUE dec
dnajb11 2.9 FALSE dec
dnajc1 33.8 TRUE inc
dnajc5aa 39.5 FALSE dec
eif2s1b 34.6 FALSE inc
ganab 34.4 FALSE dec
hsp70.1_1.2 52.7 FALSE inc
hsp70l 68.6 FALSE inc
hsp90aa1.1 17.7 FALSE inc
hspa1b 20.5 TRUE inc
hsph1 4.3 FALSE inc
march6_1.2 39.1 FALSE dec
pdia6 5.5 FALSE dec
rnf185_1.2 28.7 FALSE inc
RNF5 31.9 FALSE dec
sec61b_1.2 3.2 FALSE dec
sec61g 49.9 FALSE inc
sec62 42.1 FALSE dec
sec63 5.3 FALSE dec
selenos 3.2 FALSE U
sgta_1.2 39.5 FALSE inc
spcs2_1.2 5.5 FALSE dec
spcs3_1.2 38.9 FALSE inc
ssr2_1.2 2.8 FALSE dec
xbp1_1.2 48.4 TRUE inc
Figure 122: Table of the 40th cluster content


Cluster 50 - 21 transcripts (~ 25% < 5.55 μg/L)

Driver GO terms : COPII-coated vesicle budding

KEGG pathways : Protein processing in endoplasmic reticulum

Wikipathways :

Figure 123: DR curves for the 41st cluster
Figure 124: BMDplot for the 41st cluster
id BMD.zSD TF trend
atf6 30.3 TRUE dec
dnajb11 2.9 FALSE dec
dnajc1 33.8 TRUE inc
dnajc5aa 39.5 FALSE dec
eif2s1b 34.6 FALSE inc
ganab 34.4 FALSE dec
hsp70.1_1.2 52.7 FALSE inc
hsp70l 68.6 FALSE inc
hsp90aa1.1 17.7 FALSE inc
hspa1b 20.5 TRUE inc
hsph1 4.3 FALSE inc
march6_1.2 39.1 FALSE dec
pdia6 5.5 FALSE dec
rnf185_1.2 28.7 FALSE inc
RNF5 31.9 FALSE dec
sar1ab 41.5 FALSE inc
sar1b 3.8 FALSE dec
sec23a 5.0 FALSE dec
sec31b_1.2 37.0 FALSE dec
selenos 3.2 FALSE U
xbp1_1.2 48.4 TRUE inc
Figure 125: Table of the 41st cluster content


Cluster 19 - 20 transcripts (~ 25% < 5.86 μg/L)

Driver GO terms :

KEGG pathways : Ubiquitin mediated proteolysis

Wikipathways :

Figure 126: DR curves for the 42nd cluster
Figure 127: BMDplot for the 42nd cluster
id BMD.zSD TF trend
anapc4_1.2 4.7 FALSE inc
anapc5 23.6 FALSE inc
cbl 41.4 TRUE dec
cdc34b 31.4 FALSE dec
itcha 47.8 FALSE dec
itchb 39.3 TRUE dec
map3k1 5.2 FALSE dec
trip12_1.2 27.9 FALSE dec
uba1_1.1 45.7 FALSE dec
uba1_1.2 45.5 FALSE dec
uba7 1.8 FALSE U
ube2a_1.2 4.9 FALSE inc
ube2al 38.9 FALSE inc
ube2d2_1.3 7.3 FALSE bell
ube2d4 30.6 FALSE dec
ube2ka 37.7 FALSE inc
ube2l3b_1.1 2.4 FALSE U
UBE2M_1.4 35.4 FALSE inc
UBE2M_1.5 30.8 FALSE dec
wdr26b 6.1 FALSE dec
Figure 128: Table of the 42nd cluster content


Cluster 23 - 13 transcripts (~ 25% < 6.16 μg/L)

Driver GO terms : polyamine metabolic process

KEGG pathways : Arginine and proline metabolism

Wikipathways :

Figure 129: DR curves for the 43rd cluster
Figure 130: BMDplot for the 43rd cluster
id BMD.zSD TF trend
agmat 2.8 FALSE dec
arg2 24.5 FALSE inc
azin1b 53.0 FALSE inc
ckmb 30.6 FALSE inc
mao 2.4 FALSE dec
oat_1.2 35.2 FALSE inc
oaz2a 4.3 FALSE dec
oaz2b 45.6 FALSE inc
odc1_1.3 35.8 FALSE inc
pycr1b 31.6 FALSE inc
sat1a.2_1.2 37.4 FALSE inc
sat2b 26.9 FALSE inc
smox_1.3 6.2 FALSE inc
Figure 131: Table of the 43rd cluster content


Cluster 2 - 24 transcripts (~ 25% < 6.53 μg/L)

Driver GO terms : ATP synthesis coupled electron transport

KEGG pathways : Oxidative phosphorylation

Wikipathways : Electron transport chain, Oxidative phosphorylation

Figure 132: DR curves for the 44th cluster
Figure 133: BMDplot for the 44th cluster
id BMD.zSD TF trend
atp5f1c 24.5 FALSE inc
CABZ01102240.1_1.1 4.2 FALSE inc
cox6b2 35.3 FALSE inc
mt-atp8 34.3 FALSE inc
mt-nd1 30.2 FALSE inc
mt-nd2 5.3 FALSE inc
mt-nd3 4.3 FALSE inc
mt-nd4 3.5 FALSE inc
mt-nd4l 29.3 FALSE inc
mt-nd5 6.9 FALSE U
mt-nd6 3.6 FALSE inc
ndufaf3 31.1 FALSE inc
ndufaf5 41.4 FALSE inc
ndufb11 33.8 FALSE inc
ndufb5 40.9 FALSE inc
ndufb6 26.8 FALSE inc
ndufb8 32.8 FALSE inc
ndufb9 39.6 FALSE inc
ndufs2 40.9 FALSE inc
palb2_1.2 1.7 FALSE inc
pmpcb 24.4 FALSE inc
ppa1b 29.1 FALSE inc
sdhc_1.2 29.1 FALSE inc
ucp2 53.2 FALSE inc
Figure 134: Table of the 44th cluster content


Cluster 1 - 137 transcripts (~ 25% < 6.61 μg/L)

Driver GO terms : embryo development ending in birth or egg hatching, myeloid cell differentiation, ribosome biogenesis, translation

KEGG pathways : Ribosome

Wikipathways : Cytoplasmic ribosomal proteins

Figure 135: DR curves for the 45th cluster
Figure 136: BMDplot for the 45th cluster
id BMD.zSD TF trend
aars1_2.2 14.4 FALSE inc
ahsa1a_1.3 4.5 FALSE inc
bcl9_1.2 45.0 TRUE dec
btf3 27.6 FALSE inc
btf3l4 25.6 FALSE inc
chd7_1.3 54.7 TRUE dec
cnbpa_1.1 47.7 FALSE inc
cnot1_2.1 39.6 FALSE dec
ddx6 22.0 FALSE dec
dnm2a_1.2 2.2 FALSE dec
dohh 32.6 FALSE inc
edf1 44.6 TRUE inc
eef1a1l1_1.2 29.8 FALSE inc
eef1a1l1_1.3 49.8 FALSE dec
eif2s1b 34.6 FALSE inc
eif3ba 40.9 FALSE inc
eif3d_1.4 30.9 FALSE inc
eif3ea_1.3 5.4 FALSE inc
eif3f 35.9 FALSE inc
eif3g 28.0 FALSE inc
eif3ha 40.4 FALSE inc
eif3hb_1.2 44.7 FALSE inc
eif3i 23.9 FALSE inc
eif3jb 37.2 FALSE dec
eif3k 44.3 FALSE inc
eif3m 25.8 FALSE inc
eif4e2 4.8 FALSE inc
eif4ebp2 3.4 FALSE dec
eif4enif1_1.3 32.6 FALSE dec
eif5a2_1.2 3.0 FALSE dec
eif5b_1.2 33.2 FALSE dec
eri1_2.1 29.4 FALSE inc
faub_2.1 3.1 FALSE U
flvcr1 2.7 FALSE inc
furina_2.1 2.8 FALSE dec
gspt1 33.8 FALSE inc
hax1 27.2 FALSE inc
hdac4_1.2 34.3 TRUE dec
hmgn7_1.2 35.2 FALSE inc
insrb 35.5 FALSE dec
kat6a 42.2 TRUE dec
kif1b_1.1 5.1 FALSE dec
mdka_1.1 3.3 FALSE inc
mdka_1.2 46.7 FALSE inc
mdka_1.4 32.5 FALSE inc
meis1b_1.1 4.1 TRUE inc
mettl17_1.4 39.9 FALSE inc
mrpl15 52.5 FALSE inc
mrpl3 39.8 FALSE inc
mrpl4_1.2 36.5 FALSE inc
mrpl42 40.8 FALSE inc
mrpl43 36.3 FALSE inc
mrpl45_2.2 31.9 FALSE inc
mrps10 29.9 FALSE inc
mrps15 30.5 FALSE inc
mrps16_2.1 39.0 FALSE inc
mrps18a 27.5 FALSE inc
mrps18b 26.3 FALSE inc
mrps18c 40.1 FALSE inc
mrps22_1.4 41.8 FALSE inc
mrto4 49.4 FALSE inc
msi2b_1.6 4.1 FALSE inc
msi2b_1.8 38.4 FALSE dec
myhz1.1_2.1 2.8 FALSE inc
nip7 45.5 FALSE inc
nop53_1.2 31.6 FALSE inc
nsa2 33.4 FALSE inc
ntn1a_1.2 39.4 FALSE dec
paics_1.1 3.1 FALSE dec
pbx4_1.2 23.0 TRUE dec
pin4 37.4 FALSE inc
pitpnaa 3.1 FALSE dec
rack1_1.1 39.6 FALSE inc
rack1_1.2 6.6 FALSE inc
riox1 33.3 FALSE inc
riox2 30.4 FALSE inc
rpl10a_1.1 53.4 FALSE inc
rpl11 41.9 FALSE inc
rpl12_2.1 39.4 FALSE inc
rpl13a 39.3 FALSE inc
rpl14 6.9 FALSE inc
rpl15 42.9 FALSE inc
rpl17_1.1 4.6 FALSE inc
rpl19 35.5 FALSE inc
rpl23 43.8 FALSE inc
rpl27 45.8 FALSE inc
rpl28_1.2 2.1 FALSE inc
rpl29 51.0 FALSE inc
rpl3_1.2 7.8 FALSE inc
rpl32_2.1 25.0 FALSE inc
rpl35 8.2 FALSE inc
rpl36a_1.3 46.0 FALSE inc
rpl38 6.8 FALSE inc
rpl39 42.0 FALSE inc
rpl5a 9.0 FALSE inc
rpl7 33.3 FALSE inc
rpl7a_1.1 5.9 FALSE inc
rpl8_1.2 4.6 FALSE U
rpl9_1.1 7.0 FALSE inc
rpl9_1.2 31.1 FALSE inc
rplp0_1.2 6.2 FALSE inc
rplp2 6.0 FALSE inc
rps11 39.4 FALSE inc
rps13_1.1 3.3 FALSE dec
rps13_1.2 5.8 FALSE inc
rps15 5.8 FALSE inc
rps15a 47.0 FALSE inc
rps18_1.2 28.2 FALSE inc
rps2_1.1 42.6 FALSE inc
rps2_1.2 25.0 FALSE inc
rps24_1.1 3.4 FALSE inc
rps26 6.6 FALSE inc
rps27.1 29.3 FALSE inc
rps27.2_1.2 32.1 FALSE inc
rps27l 57.9 FALSE inc
rps29 4.8 FALSE inc
rps3a_1.1 42.5 FALSE inc
rps5 8.7 FALSE inc
rps6 36.0 FALSE inc
rps7 7.9 FALSE inc
rps8a 5.0 FALSE inc
rps9_2.1 2.6 FALSE inc
rpsa_1.2 59.0 FALSE inc
sap130b_1.2 28.7 TRUE dec
serbp1b 33.0 FALSE dec
shroom3_1.2 55.4 FALSE dec
si:ch211-207d6.2 4.3 FALSE dec
si:dkey-151g10.6 3.5 FALSE inc
si:dkey-46g23.1_1.1 40.9 FALSE dec
si:dkey-96n2.1 3.6 FALSE inc
snu13b 40.3 FALSE inc
srp54 48.8 FALSE inc
srpra 3.4 FALSE dec
tfap2c_1.2 1.6 TRUE dec
tnrc6c1_1.4 59.3 FALSE dec
UTP14C 52.0 FALSE dec
utp6_3.1 39.3 FALSE inc
Figure 137: Table of the 45th cluster content


Cluster 24 - 28 transcripts (~ 25% < 7.45 μg/L)

Driver GO terms : microtubule-based process

KEGG pathways :

Wikipathways :

Figure 138: DR curves for the 46th cluster
Figure 139: BMDplot for the 46th cluster
id BMD.zSD TF trend
cep192_1.2 40.0 FALSE inc
cep57 3.2 FALSE inc
cfap298 19.0 FALSE inc
ckap5_1.2 8.2 FALSE inc
cpeb2_1.1 3.2 FALSE bell
cpeb3 34.9 FALSE dec
CU929259.1 22.5 FALSE dec
dynll2b 3.7 FALSE inc
fyco1a_1.2 3.9 FALSE dec
gas2l1_1.2 25.8 FALSE dec
gas2l3 41.1 FALSE dec
haus4 30.8 FALSE inc
hnrnpua 45.0 FALSE dec
kif1b_1.1 5.1 FALSE dec
kif2c_1.3 39.0 FALSE inc
kifc1_1.2 26.2 FALSE inc
kifc3_1.5 45.1 FALSE dec
map1ab_1.2 39.8 FALSE dec
map4l_1.4 4.6 FALSE bell
map7d2a_1.1 58.5 FALSE dec
nckap5l 33.5 FALSE dec
plk1 45.8 FALSE inc
si:ch73-217b7.1_1.2 35.1 FALSE dec
tacc3_1.2 30.5 FALSE inc
tppp2_2.1 42.5 FALSE inc
tubb4b_1.2 2.5 FALSE dec
zgc:86764_1.2 46.1 FALSE inc
zgc:92429 35.7 FALSE inc
Figure 140: Table of the 46th cluster content


Cluster 27 - 6 transcripts (~ 25% < 7.85 μg/L)

Driver GO terms :

KEGG pathways :

Wikipathways :

Figure 141: DR curves for the 47th cluster
Figure 142: BMDplot for the 47th cluster
id BMD.zSD TF trend
bms1_2.1 2.9 FALSE dec
glmna 34.4 FALSE inc
ncoa6_1.2 2.5 FALSE inc
ncoa6_1.3 32.4 FALSE dec
ngdn 42.8 FALSE inc
pno1 22.7 FALSE inc
Figure 143: Table of the 47th cluster content


Cluster 61 - 9 transcripts (~ 25% < 9.13 μg/L)

Driver GO terms :

KEGG pathways : Adherens junction

Wikipathways :

Figure 144: DR curves for the 48th cluster
Figure 145: BMDplot for the 48th cluster
id BMD.zSD TF trend
afdna_1.1 45.2 FALSE dec
cdh1_1.2 4.4 FALSE dec
farp2_1.2 9.1 FALSE U
insrb 35.5 FALSE dec
pvrl2l 39.2 FALSE dec
si:ch73-22o12.1 36.6 FALSE dec
si:dkey-222b8.1_2.1 30.3 TRUE dec
tcf7l1a_1.2 34.9 TRUE dec
tcf7l1b_1.1 5.1 TRUE dec
Figure 146: Table of the 48th cluster content


Cluster 53 - 10 transcripts (~ 25% < 9.6 μg/L)

Driver GO terms :

KEGG pathways : Vascular smooth muscle contraction

Wikipathways :

Figure 147: DR curves for the 49th cluster
Figure 148: BMDplot for the 49th cluster
id BMD.zSD TF trend
adma 38.2 FALSE inc
gna11b 39.7 FALSE dec
gnas_1.2 34.9 FALSE dec
mylkb_1.2 2.9 FALSE dec
ppp1caa 23.1 FALSE dec
ppp1cbl 36.0 FALSE inc
ppp1r12a 31.7 FALSE dec
ppp1r14aa 63.5 FALSE inc
proca1 3.7 FALSE inc
si:ch73-265d7.2 5.1 FALSE inc
Figure 149: Table of the 49th cluster content


Cluster 35 - 47 transcripts (~ 25% < 11.62 μg/L)

Driver GO terms : ribosome biogenesis, protein glycosylation

KEGG pathways : Ribosome biogenesis in eukaryotes, N-Glycan biosynthesis, Protein processing in endoplasmic reticulum, Various types of N-glycan biosynthesis

Wikipathways :

Figure 150: DR curves for the 50th cluster
Figure 151: BMDplot for the 50th cluster
id BMD.zSD TF trend
alg11_1.2 23.4 FALSE dec
atf6 30.3 TRUE dec
crppa 19.0 FALSE inc
dnajb11 2.9 FALSE dec
dnajc1 33.8 TRUE inc
dnajc5aa 39.5 FALSE dec
eif2s1b 34.6 FALSE inc
emg1 48.1 FALSE inc
eri1_2.1 29.4 FALSE inc
ext1c_1.1 1.5 FALSE inc
ganab 34.4 FALSE dec
hsp70.1_1.2 52.7 FALSE inc
hsp70l 68.6 FALSE inc
hsp90aa1.1 17.7 FALSE inc
hspa1b 20.5 TRUE inc
hsph1 4.3 FALSE inc
man2a1 3.1 FALSE dec
march6_1.2 39.1 FALSE dec
mgat5 35.6 FALSE dec
mlec 2.9 FALSE dec
nip7 45.5 FALSE inc
nmd3 48.1 FALSE inc
noc4l 43.0 FALSE inc
nop58 2.6 FALSE dec
ogt.1_2.1 2.9 FALSE inc
pdia6 5.5 FALSE dec
pin4 37.4 FALSE inc
pomgnt1_1.2 33.9 FALSE inc
pomgnt1_2.1 36.1 FALSE inc
pomt2 29.4 FALSE inc
ran 30.5 TRUE inc
rnf185_1.2 28.7 FALSE inc
RNF5 31.9 FALSE dec
rpn1_1.2 3.3 FALSE dec
rpn2_1.1 4.0 FALSE dec
rrp7a 39.9 FALSE inc
selenos 3.2 FALSE U
snu13b 40.3 FALSE inc
srd5a3 25.2 FALSE inc
st6galnac4 23.1 FALSE dec
stt3b 3.3 FALSE dec
trub2 31.9 FALSE inc
UTP14C 52.0 FALSE dec
utp6_3.1 39.3 FALSE inc
xbp1_1.2 48.4 TRUE inc
xrn1 35.5 FALSE dec
xrn2_1.2 28.1 TRUE dec
Figure 152: Table of the 50th cluster content